Autonomic Dysfunction in Patients Following Bariatric Surgery: The ADiPOSE Study

Recruiting now

Conditions studied: Autonomic Dysfunction, Orthostatic Intolerance

In brief

Observational two phase, retrospective and prospective registry study to assess the prevalence of and characterize outcomes of autonomic dysfunction (AD) in patients who undergo bariatric surgery (BS) and to better define the underlying pathophysiology of AD following BS.

Key facts

Study ID

NCT06289413

Run by

Kansas City Heart Rhythm Research Foundation

People needed

400

Starts

2024-02-12

Expected to finish

2025-12-01

Last updated by the study team

2025-08-28

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Between the age of 18 - 85 years
• Can provide consent
• Negative urine B-hCG
• Continued follow-up with the bariatric surgery team.
• BS includes one of the following: gastric bypass, sleeve gastrectomy, and biliopancreatic diversion with duodenal switch.
• Phase I: Underwent BS within the last 3 years
• Phase II: Will undergo BS within the next 3 months or underwent BS in the last 30 days

You may not qualify if…

• Unable to provide consent
• Pregnant or breastfeeding
• BMI < 35
• Revision surgery of one of the following BS from above
• Prior history of autonomic dysfunction prior to BS
• Developed AD 72 months post-procedure
• No evidence of AD/OI

Where it is running

• Menorah Medical Center — Overland Park, Kansas, United States (enrolling)
• Bariatric and Metabolic Specialists — Overland Park, Kansas, United States (enrolling)
• Kansas City Heart Rhythm Institute - Roe Clinic — Overland Park, Kansas, United States (enrolling)
• Overland Park Regional Medical Center — Overland Park, Kansas, United States (enrolling)
• Centerpoint Medical Center Clinic — Independence, Missouri, United States (enrolling)
• Centerpoint Medical Center — Independence, Missouri, United States (enrolling)
• Research Medical Center Clinic — Kansas City, Missouri, United States (enrolling)
• Research Medical Center — Kansas City, Missouri, United States (enrolling)

Full record on ClinicalTrials.gov

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