Nerve Transfer to Improve Function in High Level Tetraplegia
Recruiting now
Conditions studied: Cervical Spinal Cord Injury, Tetraplegia
In brief
The goal of this observational study is to determine if nerve transfer surgeries improve upper extremity function and quality of life in patients with a high level cervical spinal cord injury. Participants will: * undergo standard of care pre- and post-op testing and study exams * complete pre- and post-questionnaires * undergo standard of care nerve transfer surgeries * follow-up with surgeon at 6/12/18/24/36 and potentially at 48 months * attend therapy at local therapist for up to 2 years postop.
Key facts
- Study ID
- NCT06288763
- Run by
- Washington University School of Medicine
- People needed
- 30
- Starts
- 2024-02-05
- Expected to finish
- 2028-12-31
- Last updated by the study team
- 2026-03-11
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 18-80 years of age
- High cervical SCI (motor level C1-C4)
- Motor complete SCI AIS grade A-B
- Plateaued spontaneous recovery for at least 6 months of non-operative therapy
- SCI greater than 6 months and fewer than 60 months since injury
- At least MRC 4/5 donor strength
- Mentally and physically willing and able to comply with evaluations
You may not qualify if…
- Active infection at the operative site or systemic infection
- Any return or ongoing recovery of distal motor function
- Significant joint contractures and/or limitations in passive range of motion in the arm
- Mentally or physically compromised making it impossible to complete study activities
- Immunologically suppressed
- Currently undergoing long-term steroid therapy
- Active malignancy
- Pregnancy
Where it is running
- Stanford University — Stanford, California, United States (enrolling)
- University of Miami — Miami, Florida, United States (enrolling)
- Johns Hopkins University — Baltimore, Maryland, United States (enrolling)
- University of Michigan — Ann Arbor, Michigan, United States (enrolling)
- Washington University in St. Louis — St Louis, Missouri, United States (enrolling)
- Wake Forest Medical Center — Winston-Salem, North Carolina, United States (enrolling)
- University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)
- Houston Methodist — Houston, Texas, United States (enrolling)
- University of Utah — Salt Lake City, Utah, United States (enrolling)
- University of Alberta — Edmonton, Alberta, Canada
Full record on ClinicalTrials.gov
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