Novel Telemedicine-Delivered Prolonged Exposure Therapy for Treating PTSD in Individuals With OUD
Recruiting now · Not applicable
Conditions studied: Opioid Use Disorder, Posttraumatic Stress Disorder
In brief
Among individuals with opioid use disorder (OUD), posttraumatic stress disorder (PTSD) presents a significant clinical challenge. The prevalence of PTSD is substantially higher in individuals with OUD than in the general population, with nearly 90% reporting lifetime trauma exposure and 33% meeting diagnostic criteria for PTSD. The primary objective of this study is to evaluate the efficacy of a novel telemedicine-delivered prolonged exposure therapy protocol for improving PE attendance and reducing PTSD symptom severity in individuals with concurrent PTSD and OUD.
Key facts
- Study ID
- NCT06288711
- Run by
- University of Vermont
- People needed
- 135
- Starts
- 2024-06-03
- Expected to finish
- 2027-11-30
- Last updated by the study team
- 2026-05-18
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- >18 years old
- Maintained on a stable methadone or buprenorphine dose for >1 month prior to the study
- Meet current DSM-5 posttraumatic stress disorder criteria based on the Clinician Administered PTSD Scale for DSM-5
- Participants receiving psychotropic medications must be maintained on a stable dose for >1 month prior to enrollment.
You may not qualify if…
- Current delusions or hallucinations, unstable bipolar disorder, imminent risk for suicide as assessed by the Mini International Neuropsychiatric Interview
- Cognitive impairment as evidenced by scores <22 on the Videoconference-based Mini Mental Status Examination (MMSE; Folstein, et al., 1975)
- Enrolled in another ongoing evidence-based treatment for PTSD.
- Pregnancy as verified by pregnancy test
- No access to cellular service
Where it is running
- University of Vemont — Burlington, Vermont, United States (enrolling)
Full record on ClinicalTrials.gov
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