Hypophysectomy by Stereotactic Radiosurgery for Cancer-Related Pain

Recruiting now · Phase 1

Conditions studied: Hypophysectomy

In brief

To learn if hypophysectomy (treatment of the pituitary gland) using a type of radiation treatment called stereotactic radiosurgery (SRS) can help to relieve cancer-related pain.

Key facts

Study ID

NCT06287515

Run by

M.D. Anderson Cancer Center

People needed

40

Starts

2025-01-06

Expected to finish

2027-07-01

Last updated by the study team

2026-07-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years old on the day of signing informed consent and willing and able to sign a written informed consent.
• English fluency in order to complete PROs and neurocognitive assessment
• Pathologic or cytologic confirmation of malignancy.
• Poorly controlled intractable nociceptive or mixed pain limiting function or quality of life. Participants must have exhausted or not a candidate for standard of care pain control measures such as opioids, injections/ablations, conventional radiation therapy, or surgical intervention with a curative intent and pain limiting function that affects the participants quality of life in the judgment of the treating physician. Refractory status will require at least consultation and two follow-up visits with pain specialists (pain management or supportive care).
• ECOG performance status of 0-3.
• Life expectancy is greater than 4 weeks and less than 1 year in the treating physician's judgment.

You may not qualify if…

• Participants with prior cranial or head/neck radiation where cumulative organ-at-risk dose constraints cannot be achieved (see section 4.2).
• Inability to have an MRI of the brain for reasons such as a non-compatible bioimplant that could be displaced during MRI, shrapnel embedded (such as from war wounds), metal workers, and machinists (potential for metallic fragments in or near the eyes).
• Expressions of pain due to depression, delirium or addictive behavior
• Participants who are pregnant.
• Known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the study in the judgment of the Investigators.

Where it is running

• MD Anderson Cancer Center — Houston, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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