Clinical Characteristics of Small Intestinal Bacterial Overgrowth in Individuals with Abdominal Distention
Recruiting now
Conditions studied: Abdominal Distention
In brief
Abdominal distention represents a prevalent clinical manifestation characterized by an unclear etiology and pathogenesis. This symptomatology is frequently observed in various conditions, including small intestinal bacterial overgrowth (SIBO) and abnormal orocecal transit time (OCTT). The utilization of the breath test as a non-invasive diagnostic approach has become widespread in recent years for identifying SIBO and abnormalities in OCTT. In this study, the prevalence of SIBO and OCTT irregularities in individuals presenting with abdominal distention was ascertained through the implementation of the breath test. Furthermore, the correlation between abdominal distention and SIBO/OCTT was analysed to enhance the elucidation of the underlying etiology of abdominal distention. These findings aim to offer valuable insights for refining clinical comprehension and strategies related to the diagnosis and treatment of abdominal distention.
Key facts
- Study ID
- NCT06285734
- Run by
- Shandong University
- People needed
- 402
- Starts
- 2024-03-01
- Expected to finish
- 2025-08-01
- Last updated by the study team
- 2024-12-12
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients aged 18 to 70 years.
- Patients presenting with the primary complaint of abdominal bloating and/or abdominal distension, or those exhibiting abdominal distension with prominence over other symptoms.
You may not qualify if…
- Patients who are pregnant or lactating.
- Patients have history of gastrointestinal malignancy or gastrointestinal surgery.
- Patients manifesting food intolerance or presenting with a confirmed diagnosis or suspicion of lactose intolerance.
- Patients with urinary system (chronic kidney disease, etc.), immune system (scleroderma, etc.), nervous system (Parkinson's disease, etc.), mental system (depression, etc.), or other diseases outside the digestive system.
- Patients who used antibiotics or microecological agents or underwent endoscopic examination within two weeks.
- Patients with a medication history encompassing motility enhancers, secretory enhancers, antifoaming agents, spasmolytics, opioids, and antidepressants within the past week.
- Patients who are unwilling or incapable to provide informed consents.
Where it is running
- Gastroenterology Department of Qilu Hospital — Jinan, Shandong, China (enrolling)
Full record on ClinicalTrials.gov
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