Immunomonitoring of Mold Invasive Infections
Recruiting now
Conditions studied: Invasive Fungal Disease, Mold Invasive Fungal Infection: Aspergillus, Mucorales, Fusarium, Scedosporium
In brief
Mold invasive infections are associated with an important mortality despite optimization of the antifungal treatment. In a few case reports, immune checkpoints inhibitors, initially developed for neoplastic diseases, have shown a potential beneficial effect in such devastating infections by restoring an efficient immune response. The investigators propose a longitudinal monitoring of the adaptative immune response, notably immune checkpoint expression on T cells, during mold invasive infections to help identify the patients who could benefit from the adjunction of immunotherapy and the optimal timing of such strategy.
Key facts
- Study ID
- NCT06285188
- Run by
- Assistance Publique - Hôpitaux de Paris
- People needed
- 20
- Starts
- 2025-07-28
- Expected to finish
- 2027-07-01
- Last updated by the study team
- 2025-11-20
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18 years
- Mold invasive fungal infection: Aspergillus, Mucorales, Fusarium, Scedosporium
- Proven or probable according to 2019 EORTC/MGS criteria modified by the adjunction of diabetes mellitus in the host criteria and Mucorales PCR in the microbiological criteria
- Within 14 days of IFD diagnosis or
- a refractory state defined by the 2009 MGS/EORT failure criteria (clinical, radiological, or microbiological failure) of a first-line antifungal treatment leading to a change of therapy by the attending physician of the patient
- Patients with aspergillosis or mucormycosis for whom ELISPOTs are developed: Total lymphocyte count > 700/mm3 on the last sample taken
- No opposition to participate to the research
- Affiliated or beneficiary of social security system
You may not qualify if…
- Bacterial co-infection in the last 14 days
- Previous treatment with anti-PD1 antibodies
Where it is running
- Hôpital Necker Enfants Malades — Paris, France (enrolling)
Full record on ClinicalTrials.gov
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