Interaction Between Early Trauma and Odor-induced Dopamine Release

Recruiting now · Not applicable

Conditions studied: Trauma, Psychological

In brief

This prospective, double-blind, parallel-group controlled trial aims to investigate the consequence of early trauma on dopamine release evoked by positive valence odors.

Key facts

Study ID

NCT06284382

Run by

Hôpital le Vinatier

People needed

30

Starts

2026-04-27

Expected to finish

2028-12-01

Last updated by the study team

2026-06-12

Who can join

Age: 18 and older, up to 30. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Aged 18 years or older
• Have been selected based on the Childhood Trauma Questionnaire score
• Non-smoker
• Be able to speak and read French
• Sign a consent form before intervention.

You may not qualify if…

• A pre-existing condition that affects olfaction including congenital anosmia, upper respiratory tract infection, nasal and/or sinus disease,
• Be on medication, with the exception of oral contraceptives
• Pregnant or breast-feeding woman (check with urine pregnancy tests);
• Contraindications to TMS or MRI (implanted medical devices or metallic foreign body in the head);
• Psychiatric disorders
• Use of psychotropic drugs
• Have participated in a study involving the injection of a radiotracer during the year

Where it is running

• CH le Vinatier — Bron, France (enrolling)

Full record on ClinicalTrials.gov

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