Treatment With Aspirin After Preeclampsia: TAP Trial

Recruiting now · Phase 4 · Has a placebo group

Conditions studied: Hypertensive Disorder of Pregnancy, Pre-Eclampsia, Hypertension, Eclampsia, Gestational Hypertension, Cardiovascular Diseases, Toxemia, Pregnancy Complications, Vascular Diseases, Hypertension, Pregnancy Induced, Hypertension;Pre-Eclamptic

In brief

The objective of this research project is to conduct a single-site pilot trial to assess the feasibility and effect of low-dose aspirin to augment vascular recovery in the immediate postpartum period after preeclampsia through two specific aims: 1) to pilot test the feasibility of conducting a randomized controlled trial of postpartum low dose aspirin vs. placebo, and 2) to assess the effect of postpartum aspirin on endothelial function and blood pressure. Our central hypothesis is that postpartum administration of low-dose aspirin following preeclampsia will be feasible, improve endothelial function, and lower BP at 6 months postpartum. Subjects will undergo 3 study visits involving BP measurements, blood draws, questionnaires, and/or microiontophoresis. Up to 60 adult subjects will be enrolled at Magee-Women's Hospital.

Key facts

Study ID

NCT06281665

Run by

Malamo Countouris

People needed

60

Starts

2024-05-29

Expected to finish

2027-09-01

Last updated by the study team

2026-06-04

Who can join

Age: 18 and older, up to 55. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Postpartum individuals ≥18 years old
• Preeclampsia diagnosis

You may not qualify if…

• Fetal anomaly
• Multiple gestation
• Pre-pregnancy hypertension
• Allergy or contraindication to low-dose aspirin
• Pre-pregnancy diabetes

Where it is running

• University of Pittsburgh Magee-Womens Hospital — Pittsburgh, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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