Study of Brain-spinal Cord Neural Connectivity in Spasticity

Recruiting now

Conditions studied: Spasticity, Muscle

In brief

Little is known about the peripheral and central mechanisms of action of selective dorsal rhizotomy surgery for the treatment of spasticity. A better understanding of these mechanisms will enable us to improve the surgical procedure. This will require cortico-medullo-radiculo-muscular recordings never before performed and published in the literature, and the identification of variations in connectivity correlated with the clinic.

Key facts

Study ID

NCT06281223

Run by

Fondation Ophtalmologique Adolphe de Rothschild

People needed

50

Starts

2024-02-26

Expected to finish

2026-05-01

Last updated by the study team

2025-06-11

Who can join

Age: 3 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients aged 3 to 17 years included
• scheduled for selective rhizotomy surgery
• Having received informed consent to participate in the study (written consent from both parents)
• Affiliated or beneficiary of a social security scheme

You may not qualify if…

• Contraindications to selective rhizotomy
• History of epilepsy
• Known neurological and/or psychiatric disorders with past and/or current medical treatment, or drug addiction
• Patient under legal protection
• Pregnant or breast-feeding women

Where it is running

• Hpu Lenval — Nice, France (enrolling)
• HFAR — Paris, France (enrolling)

Full record on ClinicalTrials.gov

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