Investigation of the Influence of the Human Microbiome on Giant Cell Arteritis
Recruiting now
Conditions studied: Giant Cell Arteritis
In brief
The longitudinal observational study aims to assess the impact of the microbiome especially the gut-microbiome in the emergence and course of giant cell arteritis (abbr. GCA) patients. At diagnosis and 6 month follow up we will analyze the oral, blood and gut microbiome from GCA patients and healthy controls. Thereby identified potential candidate biota will be further analyzed for possible interactions and influence on the immune system.
Key facts
- Study ID
- NCT06279065
- Run by
- University of Bonn
- People needed
- 50
- Starts
- 2024-02-29
- Expected to finish
- 2028-02-01
- Last updated by the study team
- 2024-05-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Diagnosis of Giant cell arteritis (only in one arm)
You may not qualify if…
- chronic infection (viral, fungi, bacteria) including human immunodeficiency viruses, Hepatitis B/C
- acute infection with usage of antibiotics less then 90 days before screening
- major gastro-intestinal surgery <5 years from screening
- gastro-intestinal bleeding <90 days before screening
- inflammatory bowel disease (confirmed bioptically)
- bulimia or anorexia nervosa
- adipositas (body mass index ≥ 40)
- intake of high dosage of probiotics (>10\^9 colony forming units per day) <90 days before screening
- not controlled Diabetes mellitus
- Malignancy within one year (except for squamous skin - and basal skin carcinoma without metastasis, cervix carcinoma with curative surgery, Cutaneous T-cell lymphoma)
- known abuse of alcohol oder drugs.
Where it is running
- Clinic of Internal Medicine III, Department of Oncology, Haematology, Rheumatology and Clinical Immunology, University Hospital Bonn — Bonn, North Rhine-Westphalia, Germany (enrolling)
- University Hospital Bonn — Bonn, Germany (enrolling)
Full record on ClinicalTrials.gov
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