Effect of Mutations in T2DM Susceptibility Genes on the Expression of Susceptibility Genes in Patients With T2DM and Controls
Recruiting now · Not applicable
Conditions studied: Type 2 Diabetes Mellitus, Gene Polymorphisms, Genetic Mutations, Susceptibility, Genetic
In brief
In this study, investigators wanted to determine the effect of T2DM susceptibility gene mutations on self-expression. Participants (T2DM patients and controls) were recruited to identify genotypes and detect the levels of T2DM susceptibility genes expression in the fresh peripheral plasma. The normal pancreatic tissues or adjacent tissues of pancreatic cancer were also collected to identify the expression differences of T2DM susceptibility genes under different genotypes.
Key facts
- Study ID
- NCT06277466
- Run by
- The Affiliated Hospital of Xuzhou Medical University
- People needed
- 300
- Starts
- 2024-01-01
- Expected to finish
- 2028-01-31
- Last updated by the study team
- 2024-02-28
Who can join
Age: 25 and older, up to 70. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- no drug therapy; 25 to 70 years old; Hemoglobin A1c (HbA1c) 7%-12%; BMI 20-35 kg/m2; Stable body weight (≤10% change within 3 months)（For newly diagnosed patients with T2DM）.
- 25 to 60 years old; BMI 19-26 kg/m2; in good health, with no abnormalities of motor system, digestive system, respiratory system, urogenital system, blood system, circulatory system, nervous/mental system, endocrine system, etc（For healthy subjects）.
- 20-80 years old; surgical resection of part or all of the pancreas; pancreatic lesions confirmed by enhanced CT or magnetic resonance (MR) examination or confirmed by intraoperative and postoperative pathology（For the patients in general surgical）.
You may not qualify if…
- had taken antidiabetic drugs;
- had a history of pancreatic surgery;
- Complicated with severe organ lesions;
- Long-term use of drugs that affect pancreatic function.
Where it is running
- China, Jiangsu, Department of Endocrinology — Xuzhou, China (enrolling)
Full record on ClinicalTrials.gov
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