Exercise in Patients With Hypermobile Joints and Knee Pain
Recruiting now · Not applicable
Conditions studied: Hypermobility, Joint, Hypermobility Syndrome, Knee Discomfort
In brief
Pain associated with knee joint hypermobility is common in the adult population, but evidence on treatment is sparse. This study investigates if high-load resistance training is superior to usual care in improving activity-related pain in young patients (18-45 years) with hypermobile joints and knee pain.
Key facts
- Study ID
- NCT06277401
- Run by
- University of Southern Denmark
- People needed
- 90
- Starts
- 2024-02-21
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2026-04-29
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Persistent knee pain for ≥ 3 months (self-reported)
- Knee pain ≥ 30mm during the last week using a 0-100 mm visual analogue scale (VAS; 0=no pain and 100=worst imaginable pain) (self-reported)
- Generalised joint hypermobility assessed with the Five-Part Hypermobility Questionnaire (positive ≥ 2/5) (self-reported)
- Local knee joint hypermobility using the passive hyperextension of the knee in standing (positive > 10 degrees of hyperextension) and confirmed in supine lying (heel resting on 20 cm high block on the bench surface), with passive knee hyperextension (positive > 10 degrees) (objectively measured)
You may not qualify if…
- Diagnosed with patellar tendinopathy
- Pregnancy or childbirth within the past year (due to increased levels of relaxin that could affect joint stability)
- Knee surgery within the past year
- Participation in regular structured resistance training within the past six months
- Inability to speak and understand Danish.
- All types of Ehlers-Danlos syndrome
- Other heritable connective tissue disorders such as Marfan syndrome, osteogenesis imperfecta, Loeys-Dietz syndrome, Stickler syndrome, skeletal dysplasias
- Autoimmune rheumatic connective tissue disorders such as lupus, rheumatoid arthritis; Chromosomal conditions such as Fragile X syndrome, Kabuki syndrome, Down syndrome
- Neuromuscular disorders that can cause joints to become unstable, such as multiple sclerosis
Where it is running
- Physiotherapy Clinics Region of Southern Denmark — Odense, Fyn, Denmark (enrolling)
- University of Southern Denmark — Odense, Fyn, Denmark (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.