HONEY for the Treatment of POst-Tonsillectomy Pain
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Post Surgical Pain, Analgesia
In brief
Double-blind, randomised, placebo controlled, single-site trial in adults to compare the effect of Manuka honey with standard of care compared to placebo with standard of care on post-tonsillectomy pain and postoperative outcomes. Main aim is to investigate a potential improvement in post-tonsillectomy pain control, with a low cost and freely available alternative to conventional analgesics. Recent systematic review and multidisciplinary consensus suggest a potential role for the inclusion of honey for this purpose. Clinical efficacy over placebo remains to be conclusively demonstrated in robust clinical trials.
Key facts
- Study ID
- NCT06275698
- Run by
- East and North Hertfordshire NHS Trust
- People needed
- 100
- Starts
- 2023-09-04
- Expected to finish
- 2027-07-31
- Last updated by the study team
- 2026-07-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Adult (≥18years old at the time of giving consent)
- Consented and listed for bilateral tonsillectomy or adenotonsillectomy
- Tonsillectomy performed within the trial study period
You may not qualify if…
- Any concurrent Head \& Neck (H\&N) malignancy
- Unilateral tonsillectomy
- Pregnancy
- Concurrent pharyngeal or upper aerodigestive tract biopsy
- Robotic tonsillectomy
- Previous H\&N malignancy
- Previous H\&N radiotherapy
- Type 1/2 diabetes mellitus
- Known allergy to bee related products
- Known allergy to golden syrup
- History of chronic pain
- History of fibromyalgia
- Current usage of chronic (>6weeks) analgesia
- High-risk anaesthetic patients
- Children or adolescents <18years old
- Adults unable to consent for themselves
Where it is running
- Lister Hospital — Stevenage, United Kingdom (enrolling)
Full record on ClinicalTrials.gov
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