Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)
Recruiting now · Phase 2/Phase 3 · Has a placebo group
Conditions studied: Anxiety Disorders, Depression, Post Traumatic Stress Disorder
In brief
The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. Participants will be randomly assigned to one of two groups. Group 1 will receive a computer-based program that is designed as a cognitive training intervention and Group 2 will receive a similar computer-based exercise that researchers think will be less effective in training thinking skills (also known as a control or sham condition). Participants will be compared on cognitive performance and brain response during cognitive tasks from baseline to post-treatment.
Key facts
- Study ID
- NCT06273527
- Run by
- University of California, San Diego
- People needed
- 128
- Starts
- 2024-10-01
- Expected to finish
- 2027-08-01
- Last updated by the study team
- 2025-10-24
Who can join
Age: 21 and older, up to 55. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- age 21-55
- fluent in English
- diagnosis of mood, anxiety, or traumatic stress disorder
- clinically elevated repetitive negative thinking
- outpatient status
- 6-week stability if taking selective serotonin reuptake inhibitor (SSRI) medications
You may not qualify if…
- past year diagnosis of severe alcohol or moderate or greater substance use disorder
- lifetime history of psychotic or bipolar I disorder
- acute suicidality necessitating immediate clinical intervention
- neurodegenerative or neurodevelopmental disorders
- history of moderate or severe traumatic brain injury or other known neurological condition
- sensory deficits that would preclude completing tasks
- conditions unsafe for completing MRI scanning (e.g., metal in body)
- current pregnancy
- currently receiving psychosocial treatment
- currently receiving psychiatric pharmacotherapy, except SSRIs
Where it is running
- UC San Diego — San Diego, California, United States (enrolling)
Full record on ClinicalTrials.gov
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