Swab Testing to Optimize Pneumonia Treatment With Empiric Vancomycin

Completed · Not applicable

Conditions studied: Community-acquired Pneumonia

In brief

This is a single center, pragmatic, randomized clinical trial (pRCT) examining whether reporting the results of a negative rapid PCR back to the provider via a pager alert results in decreased vancomycin utilization for critically ill adults with community-acquired pneumonia when compared with usual care.

Key facts

Study ID: NCT06272994
Run by: Vanderbilt University Medical Center
People needed: 277
Starts: 2024-04-03
Expected to finish: 2025-02-27
Last updated by the study team: 2026-02-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Adult (age greater than or equal to 18) patients admitted/transferred to the Vanderbilt University Medical Center (VUMC) Medical Intensive Care Unit (MICU) from the VUMC Emergency Department or from a hospital floor within 48 hours of admission.
Suspicion for pneumonia on admission (defined as an indication for antibiotics of "respiratory infection" and/or an order for a respiratory culture i.e., sputum culture, tracheal aspirate culture, or bronchoalveolar lavage (BAL) culture).
No topical nasal decolonization during hospitalization prior to collection of MRSA nasal swab PCR.
Must match both of the following in either order:
The patient has been admitted to and physically located in the MICU.
The patient has received a continuing vancomycin order, or a pharmacokinetics consult for a continuing vancomycin order, no later than 24 hours following their physical admission to the MICU.

You may not qualify if…

Hospital stay of longer than 48 hours prior to MICU admission.
Known to be a prisoner

Where it is running

Vanderbilt University Medical Center — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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