Zilebesiran as Add-on Therapy in Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications (KARDIA-3)
Completed · Phase 2 · Has a placebo group
Conditions studied: High Cardiovascular Risk, Hypertension
In brief
The purpose of this study is to evaluate the effect of zilebesiran as add-on therapy in patients with high cardiovascular risk and hypertension not adequately controlled by standard of care antihypertensive medications.
Key facts
- Study ID
- NCT06272487
- Run by
- Alnylam Pharmaceuticals
- People needed
- 375
- Starts
- 2024-02-29
- Expected to finish
- 2025-12-01
- Last updated by the study team
- 2026-03-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- History of cardiovascular (CV) disease, high CV risk, or estimated glomerular filtration rate (eGFR) ≥30 to <60 mL/min/1.73m\^2
- Mean seated office SBP ≥140 mmHg and ≤170 mmHg
- 24-hour mean SBP ≥130 mmHg and ≤170 mmHg assessed by ABPM
- Must be on stable therapy with 2 to 4 classes of antihypertensive medications
You may not qualify if…
- Secondary hypertension
- Orthostatic hypotension
- Proteinuria >3 g/day
- Serum potassium >4.8 milliequivalents per liter (mEq/L)
Where it is running
- Clinical Trial Site — Daphne, Alabama, United States
- Clinical Trial Site — Foley, Alabama, United States
- Clinical Trial Site — Huntsville, Alabama, United States
- Clinical Trial Site — Huntsville, Alabama, United States
- Clinical Trial Site — Montgomery, Alabama, United States
- Clinical Trial Site — Gilbert, Arizona, United States
- Clinical Trial Site — Phoenix, Arizona, United States
- Clinical Trial Site — Sun City, Arizona, United States
- Clinical Trial Site — Tempe, Arizona, United States
- Clinical Trial Site — Tucson, Arizona, United States
- Clinical Trial Site — Beverly Hills, California, United States
- Clinical Trial Site — Covina, California, United States
- Clinical Trial Site — Encinitas, California, United States
- Clinical Trial Site — Garden Grove, California, United States
- Clinical Trial Site — Huntington Beach, California, United States
- Clinical Trial Site — Los Angeles, California, United States
- Clinical Trial Site — Los Angeles, California, United States
- Clinical Trial Site — Northridge, California, United States
- Clinical Trial Site — Northridge, California, United States
- Clinical Trial Site — Pasadena, California, United States
- Clinical Trial Site — San Diego, California, United States
- Clinical Trial Site — San Diego, California, United States
- Clinical Trial Site — San Dimas, California, United States
- Clinical Trial Site — Simi Valley, California, United States
- Clinical Trial Site — Alexander City, Alabama, United States
Full record on ClinicalTrials.gov
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