Comparison of Intravenous Lidocaine vs Ketamine in Colorectal Surgery

Recruiting now · Not applicable

Conditions studied: Colorectal (Colon or Rectal) Cancer, Inflammation

In brief

Patients undergoing open colorectal surgery were randomly divided into two groups: Intravenous Lidocaine (IV-Lido) vs Intravenous Ketamine (IV-Keta). For the IV-Lido group, patients received a loading dose of Lidocaine than a continuous infusion over twenty-four hours. For the IV-Keta goup, patients received a loading dose of Ketamine than a continuous injection of Ketamine over twenty-four hours. Plasma concentrations of Interleukin-6(IL-6) were measured preoperatively before anesthetic induction and at twenty-four hour post operatively.

Key facts

Study ID

NCT06272461

Run by

University Tunis El Manar

People needed

50

Starts

2023-10-01

Expected to finish

2026-03-30

Last updated by the study team

2025-11-18

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients aged 18 or older.
• American society of anesthesiologists' (ASA) physical status of I-III.
• Elective open colorectal surgery.
• NON INCLUSION CRITERIA:
• Patients with contraindications to lidocaine or ketamine.
• Corticosteroid therapy within the last 6 months.
• History of immunosuppressive therapy.
• History of surgery in the last 3 months.
• Personal medical history of inflammatory bowel disease.
• Personal medical history of cardiac arrythmias or conduction disorders.
• Alcohol or drug abuse.
• Chronic use of opioids or benzodiazepines.

You may not qualify if…

• Severe intraoperative complications.
• Duration of surgery longer than 5 hours.

Where it is running

• Tunisia — Nabeul, Tunisia (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.