Tumor Microenvironment in Ovarian Cancer

Recruiting now

Conditions studied: Ovarian Cancer Stage III, Ovarian Cancer Stage IV

In brief

A detailed understanding of molecular mechanism of cancer genesis is fundamental to develop innovative and personalized therapies. The new frontier in biomedical research is represented by organoids, a three-dimensional cell culture system obtained from a tissue fragment that accurately reproduces the essential properties of the original tissue in vitro, which could provide a valuable model for explanation of ovarian cancers pathogenesis and will allow to predict the response to a specific therapy. With this research project, we expect to generate ovarian cancer organoids to characterize in vitro interactions and molecular pathway among tumor cells, immune cells, and resident microbiota (intratumoral bacteria and/or microbial-derived molecules).

Key facts

Study ID

NCT06272240

Run by

University of Udine

People needed

50

Starts

2024-01-02

Expected to finish

2027-01-01

Last updated by the study team

2024-02-22

Who can join

Age: 18 and older, up to 80. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Age > 18 years
• Age < 80 years
• Serous ovarian carcinoma
• FIGO Stage III-IV

You may not qualify if…

• Ongoing or suspended immunosuppressive therapy within the last 6 months
• Congenital or acquired immunodeficiency
• Immunosuppressive state
• Administration of chemotherapy for another neoplasm in the past 12 months
• Non-epithelial ovarian tumors
• Patients not undergoing surgical intervention
• BMI > 30
• Absence of Informed Consent

Where it is running

• Università degli Studi di Udine — Udine, UD, Italy (enrolling)

Full record on ClinicalTrials.gov

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