Reducing Neoplasia Recurrence After Endoscopic Resection of Large Colorectal Polyps
Recruiting now · Not applicable
Conditions studied: Colorectal Cancer, Polyp of Colon
In brief
Large (≥20mm) colorectal polyps often harbor areas of advanced neoplasia, making them immediate colorectal cancer (CRC) precursors. Such polyps have to be completely removed to prevent CRC and to avoid surgery and/or adjuvant therapy. The laterally spreading lesions (LSLs) are removed via endoscopic mucosal resection (EMR). However, recurrence is common. New techniques for LSL resection (hybrid argon plasma coagulation (h-APC) margin and base ablation) have shown a reduction in recurrence following the interventions. We hypothesize that performing hybrid argon plasma coagulation (h-APC) margin and base ablation during EMR of large (≥20mm) colorectal LSLs will lead to lower rates of lesion recurrence compared to Snare tip soft coagulation (STSC) margin ablation.
Key facts
- Study ID
- NCT06271941
- Run by
- Centre hospitalier de l'Université de Montréal (CHUM)
- People needed
- 892
- Starts
- 2024-07-19
- Expected to finish
- 2028-04-01
- Last updated by the study team
- 2024-11-25
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- adult ≥18 years old
- patients undergoing EMR for a large (≥20mm) colorectal LSL
- patients providing written and informed consent for study participation.
You may not qualify if…
- inflammatory bowel disease;
- non-elective colonoscopy;
- poor general health (American Society of Anesthesiologists classification >III);
- coagulopathy or thrombocytopenia (international normalized ratio ≥1.5 or platelets <50 x 109/L);
- pedunculated polyps (Paris class Ip, Isp);
- overt signs of deep submucosal invasive cancer (JNET 3);
- biopsy proven invasive carcinoma in a potential study polyp.
- Pregnant women
Where it is running
- Centre Hospitalier de l'Université de Montréal — Montreal, Quebec, Canada (enrolling)
Full record on ClinicalTrials.gov
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