TMS for Veterans Attending a 2-week Intensive Outpatient Program for PTSD
Completed · Not applicable
Conditions studied: PTSD
In brief
The goal of this study is to determine whether complementing regular intensive PTSD treatment with intermittent theta burst stimulation (iTBS) applied to the right dorsolateral prefrontal cortex (DLPFC) can improve treatment response for individuals attending a 2-week intensive outpatient program (IOP) for PTSD.
Key facts
- Study ID
- NCT06271733
- Run by
- Rush University Medical Center
- People needed
- 6
- Starts
- 2022-01-11
- Expected to finish
- 2025-10-27
- Last updated by the study team
- 2026-02-20
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Veterans or service members between the ages of 18 and 65 who are attending the 2- week Intensive Outpatient Program at the Road Home Program and have not had significant PTSD symptom change based on the PCL-5 during the first week of treatment.
- Participants with an HDRS-21 score ≤ 26 at screening visit
You may not qualify if…
- Individuals with implants and non-removable metals which prevent them from safely receiving TMS, including:
- Aneurysm clips or coils
- Stents in the head, neck, or brain
- Deep brain stimulators
- Metallic implants in the head, neck, or brain (braces and dental implants do not interfere and are safe for TMS)
- Shrapnel or bullet fragments in or near the head
- Facial tattoos with metallic or magnetic-sensitive ink
- Other metal devices or ferromagnetic objects implanted in or near the head
- Pacemakers, intra-cardiac lines, or implanted medical pumps
- Individuals with a history of seizures or epilepsy (except those therapeutically induced by ECT)
- Individuals diagnosed with major, chronic mental health illnesses such as Psychotic Disorders, Bipolar Disorders, and Obsessive Compulsive Disorder
- Individuals with a history of substance abuse within the past six months
- Individuals with significant neurological disorders such as Parkinson's disease, Huntington's chorea, and Multiple sclerosis
- Individuals with unstable physical disease, such as unstable cardiac diseases
- Individuals currently on Benzodiazepine at a dose higher than 3mg or Lorazepam or equivalent.
- Women who are breastfeeding or pregnant
- Individuals with previous TMS treatment
Where it is running
- Rush University Medical Center — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
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