The Effect of Local Application of Tranexamic Acid Versus Placebo on Postoperative Complications in Plastic Surgery
Recruiting now · Phase 4 · Has a placebo group
Conditions studied: Surgical Complication
In brief
Study objective: This is a study to investigate whether applying the drug tranexamic acid (TXA) onto a surgical wound surface may affect the incidence of surgical complications such as re-bleeding needing intervention, wound complications such as infection, wound rupture or seroma, or if it may increase the risk of blood clots. Eligible patients: Patients undergoing plastic surgical procedures with wounds that would normally receive application of TXA to reduce bleeding after surgery. Study intervention: Participants will receive a single local application of study drug onto their wound surfaces at the end of surgery. Study drug will be identical looking ampoules which contain either TXA or placebo (saline). Neither participants nor study personnel will know the contents of the ampoules.
Key facts
- Study ID
- NCT06270407
- Run by
- St. Olavs Hospital
- People needed
- 3000
- Starts
- 2024-10-01
- Expected to finish
- 2029-12-31
- Last updated by the study team
- 2024-12-04
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients are eligible to be included in the study only if all of the following criteria apply:
- They are to undergo a surgical procedure within the field of plastic surgery where the procedure involves use of topical TXA at the participating center.
- They are over 18 years of age and capable of independently providing informed consent
- They have received adequate oral and written information about the study and signed the informed-consent form
You may not qualify if…
- Patients with known allergy to tranexamic acid. Insufficient knowledge of national language or English.
Where it is running
- St Olav's University Hospital — Trondheim, Norway (enrolling)
Full record on ClinicalTrials.gov
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