A Research Study to See How Well New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Levels in People With Type 2 Diabetes (T2D), Compared to Daily Insulin Glargine (COMBINE 4)

Completed · Phase 3

Conditions studied: Type 2 Diabetes

In brief

This study will compare the new medicine IcoSema, which is a combination of insulin icodec and semaglutide, taken once a week, to insulin glargine (mentioned as insulin glargine in this form) taken daily in people with type 2 diabetes. The study will look at how well IcoSema controls blood sugar levels as compared to insulin glargine in people with type 2 diabetes who do not have their blood sugar properly controlled with other oral diabetes medicines. Participant will either get IcoSema or insulin glargine. Which treatment participants get is decided by chance. IcoSema is a new medicine that doctors cannot prescribe. Doctors can already prescribe insulin glargine in many countries. The study will last for about 11 months (47 weeks).

Key facts

Study ID

NCT06269107

Run by

Novo Nordisk A/S

People needed

485

Starts

2024-02-15

Expected to finish

2025-07-08

Last updated by the study team

2026-06-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female and age above or equal to 18 years at the time of signing the informed consent.
• Diagnosed with T2D greater than or equal to (≥) 180 days before screening.
• HbA1c ≥ 8.0% (≥ 64.0 millimoles per mole [mmol/mol]) as assessed by central laboratory on the day of screening.
• Insulin naïve. Short term insulin treatment for a maximum of 14 consecutive days before screening is allowed, as is prior insulin treatment for gestational diabetes.
• Currently treated with 1-3 oral anti diabetic drug (OADs) with stable daily doses ≥ 90 days before screening comprising any of the following anti diabetic drug(s) at effective or maximum tolerated dose.
• Metformin
• Sulfonylureas
• Meglitinides (glinides)
• Dipeptidyl peptidase (DPP) 4 inhibitors
• Sodium glucose co transporter 2 inhibitors
• Alpha glucosidase inhibitors
• Thiazolidinediones
• Marketed oral combination products only including the products listed above.
• Body mass index (BMI) less than or equal to (≤) 40.0 kilogram per square meter (kg/m\^2).

You may not qualify if…

• Female who is pregnant, breast-feeding or intends to become pregnant or is of childbaring potential and not using highly effective contraceptive method.
• Anticipated initiation or change in concomitant medication (for more than 14 consecutive days) known to affect weight or glucose metabolism (e.g. treatment with orlistat, thyroid hormones, or systemic corticosteroids).
• Any episodes of diabetic ketoacidosis or treatment with any medication for the indication of diabetes or obesity other than stated in the inclusion criteria within 90 days before screening.
• Presence or history of pancreatitis (acute or chronic) within 180 days before screening.
• Any of the following: Myocardial infarction, stroke, hospitalization for unstable angina pectoris or transient ischaemic attack within 180 days before screening.
• Chronic heart failure classified as being in New York Heart Association Class IV at screening.
• Recurrent severe hypoglycaemic episodes within the last year (12 months) as judged by the investigator.
• Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Verified by a fundus examination performed within the past 90 days before screening or in the period between screening and randomisation. Pharmacological pupil dilation is a requirement unless using a digital fundus photography camera specified for non dilated examination.

Where it is running

• John Muir Physicians Network — Concord, California, United States
• Scripps Whittier Diabetes Inst — La Jolla, California, United States
• First Valley Med Grp Lancaster — Lancaster, California, United States
• Clinical Trials Research_Sacramento — Lincoln, California, United States
• Desert Oasis Hlthcr Med Group — Palm Springs, California, United States
• Desert Oasis Hlthcr Med Group — Palm Springs, California, United States
• Northeast Research Institute — Fleming Island, Florida, United States
• East Coast Institute For Research — Jacksonville, Florida, United States
• Clinical Research of Cent FL — Winter Haven, Florida, United States
• Atlanta Diabetes Associates — Atlanta, Georgia, United States
• Endo Res Solutions Inc — Roswell, Georgia, United States
• East West Medical Research Institute_Honolulu — Honolulu, Hawaii, United States
• Elite Clinical Trials — Blackfoot, Idaho, United States
• Cedar-Crosse Research Center — Chicago, Illinois, United States
• Endeavor Health — Skokie, Illinois, United States
• Cotton-O'Neil Diab & Endo Ctr — Topeka, Kansas, United States
• The Research Group of Lexington LLC — Lexington, Kentucky, United States
• Endo and Metab Consultants — Rockville, Maryland, United States
• Methodist Phys. Clinic — Omaha, Nebraska, United States
• Albuquerque Clin Trials, Inc. — Albuquerque, New Mexico, United States
• AMC Community Endocrinology — Albany, New York, United States
• Southgate Medical Group, LLP — West Seneca, New York, United States
• PharmQuest Life Sciences LLC — Greensboro, North Carolina, United States
• Physician's East Endocrinology — Greenville, North Carolina, United States
• Univ of Alabama_Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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