Detection of Endometrial Cancer Through Risk Modelling
Recruiting now
Conditions studied: Endometrial Cancer
In brief
The study goal is to investigate a non-invasive approach to predict endometrial cancer (EC) risk, better understand disease progression and identify opportunities for intervention. This two-part case-cohort prospective study will recruit patients whose abnormal uterine bleeding is being evaluated via endometrial biopsy. Participants will complete an online health questionnaire, and a subset will be invited to self-collect vaginal samples for sequencing. Selected sequenced participants will be invited for longitudinal monitoring (questionnaires, wearable fitness tracker) and an additional vaginal self-collection to identify persistent genetic mutations or microbiome alterations 6-8 months later.
Key facts
- Study ID
- NCT06268626
- Run by
- University of British Columbia
- People needed
- 1000
- Starts
- 2024-10-10
- Expected to finish
- 2027-01-01
- Last updated by the study team
- 2026-04-16
Who can join
Age: 40 and older. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Study Part A:
- 40 years and older
- Experiencing unexplained abnormal uterine bleeding (i.e., not from IUD, etc.)
- Have an intact uterus
- Referred for an endometrial biopsy
- Study Part B/Longitudinal monitoring:
- Those selected for sequencing (from Part A) and who retained their uterus.
You may not qualify if…
- Study Part A:
- Endometrial sampling, pelvic radiation, or vaginal infection (vaginosis, yeast) in the past 3 months
- Started hormone therapy (HRT, birth control, IUD) in the past year (with the exception of tamoxifen)
- Intercourse, vaginal product use, or douching in the past 48 hours
- Study Part B/Longitudinal monitoring:
- Same as Study Part A
- EC or EIN, or anyone who is recommended a hysterectomy
Where it is running
- VGH Research Pavilion — Vancouver, British Columbia, Canada (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.