Direct Portal Pressure Measurement Via Endoscopic Ultrasound in Advanced Chronic Liver Disease (EVADIPP)

Recruiting now

Conditions studied: Portal Hypertension

In brief

A minimally invasive procedure to directly assess portal pressure gradient under endoscopic ultrasound guidance (EUS-PPG) has become available and initial data have proved the technique to be safe. Aims of our proposal are: (i) to assess performance of EUS-PPG as compared to HVPG in evaluating hemodynamic response to non selective betablockers (NSBBs) in a large cohort of patients with CSPH;(ii) identification of markers of hemodynamic response(iii) identification of factors potentially affecting the accuracy of PPG measurement.

Key facts

Study ID

NCT06266260

Run by

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

People needed

50

Starts

2023-09-11

Expected to finish

2026-04-01

Last updated by the study team

2025-03-14

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with newly diagnosed esophago-gastric varices or with high suspicion of CSPH at non-invasive tests (porto- systemic collaterals at imaging, platelet count <150.000 x mm3, spleen size >13 cm in the largest axis, alteration of elastography parameters of the liver or spleen)
• naïve to treatment with NSBBs,

You may not qualify if…

• Child Pugh >A6
• Hepatocellular carcinoma
• Portal vein thrombosis

Where it is running

• Policlinico Gemelli IRCCS — Roma, Italy (enrolling)

Full record on ClinicalTrials.gov

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