Specific Versus Empirical Anthelminthic Treatment in Eosinophilia

Recruiting now · Not applicable

Conditions studied: Eosinophilia

In brief

There are a few guidelines recommend about management of eosinophilia worldwide, most of guielines recommend a thorough history-taking and physical examination. Subsequently, investigations are requested based on suspected causes. In cases where parasite infection is suspected, particularly in developing countries, stool microscopy and serology are recommended. However, limitations such as low sensitivity of stool microscopy, the inconvenience of collecting multiple stool samples, and the high cost and unavailability of serology may arise. Consequently, some physicians opt for empiric anthelminthic regimens in managing eosinophilic patients, even without stool tests or if stool test results are normal. If subsequent complete blood count (CBC) results show a recovery of absolute eosinophil count, it is assumed that eosinophilia was caused by a parasite infection. While some studies demonstrate the efficacy and simplicity of this approach, there is a risk of overestimating parasite infection in eosinophilic patients, potential adverse drug reactions from unnecessary anthelminthic treatment, and the possibility of drug resistance due to inappropriate dosing. To address this gap, no study has yet compared the efficacy between specific anthelminthic treatment based on test results and empirical anthelminthic treatment in eosinophilic patients. Therefore, the investigators are conducting this study.

Key facts

Study ID: NCT06265870
Run by: Prince of Songkla University
People needed: 700
Starts: 2024-05-01
Expected to finish: 2025-12-31
Last updated by the study team: 2024-09-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Participants who come for check-ups at general practitioner, primary care unit, and Srivejchavat Premium Center have an absolute eosinophil count greater than 500 cells/microliter with a white blood cell count less than 10,000 cells/microliter.
Age at least 18 years old
Consent to participate in research

You may not qualify if…

Having any characteristics that need urgent care 1.1 Having history of unintended significant weight loss is defined as the loss of body weight exceeding 10% within a span of six months without deliberate attention.
2 Physical examination revealed a body temperature equal to or greater than 37.8 degrees Celsius, lymphadenopathy or hepatosplenomegaly.
3 CBC revealed blast cell
Receiving anthelminthic drug within 6 months
Underlying cancer (active stage), HIV, HBV, HCV, collagen vascular disease, active TB
Allergy to albendazole, ivermectin, or metronidazole
Pregnancy or lactation
Serum transaminase higher than 2 times of upper normal limit
Taking medications that may induce eosinophilia within the past three months, such as herbal supplements, NSAIDs, Salicylic acid, Carbamazepine, Colchicine, Nitrofurantoin, Dapsone, or Minocycline, was reported.

Where it is running

Prince of Songkla University - Hat Yai Campus: Prince of Songkla University — Hat Yai, Changwat Songkhla, Thailand (enrolling)

Full record on ClinicalTrials.gov

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