Multi-hospital Electronic Decision Support for Drug-associated Acute Kidney Injury

Completed · Not applicable

Conditions studied: Acute Kidney Injury

In brief

This study is a randomized controlled trial at eight hospitals within the University of Pittsburgh Medical Center-UPMC system. The project will assess the efficacy of a clinical surveillance system augmented with near real-time predictive analytics to support a pharmacist-led intervention delivered to attending physicians (primary service) to reduce the progression and complications of drug-associated acute kidney injury (D-AKI) in hospitalized (non-ICU) adults.

Key facts

Study ID

NCT06264752

Run by

University of Pittsburgh

People needed

698

Starts

2024-02-15

Expected to finish

2025-07-15

Last updated by the study team

2025-09-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Physician-subject Inclusion
• Physicians employed at UPMC hospital systems
• Attending physicians of record who care for patients across multiple units outside ICU/ED
• Physician cares for 1 or more patient receiving a system alert identifying high-risk for AKI
• Patient-subject Inclusion
• System alert identifying risk for AKI
• Patient has attending physician who is participating in the randomized clusters
• After initial patient inclusion, an individual patient will not be eligible for re-inclusion until after 90 days. Re-inclusion will only be allowed if a separate hospital admission/encounter occurs and only starting on day 91

You may not qualify if…

• Physician-subject Exclusion
• Physicians of record who only care for ICU or ED patients
• Physicians who primarily provide care for transplant (heart, kidney, liver, etc.) patients
• Physicians who primarily provide consult services only (dermatology, rehabilitation, etc.)
• Patient-subject Exclusion
• Patients with end stage renal disease on admission, baseline eGFR <15, comfort measures only, or died before the intervention could be delivered

Where it is running

• UPMC Altoona — Altoona, Pennsylvania, United States
• UPMC Horizon — Farrell, Pennsylvania, United States
• UPMC McKeesport — McKeesport, Pennsylvania, United States
• UPMC Jameson — New Castle, Pennsylvania, United States
• UPMC Magee — Pittsburgh, Pennsylvania, United States
• UPMC Presbyterian/Montefiore — Pittsburgh, Pennsylvania, United States
• UPMC Shadyside — Pittsburgh, Pennsylvania, United States
• UPMC Williamsport — Williamsport, Pennsylvania, United States

Full record on ClinicalTrials.gov

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