Applying Directly Observed Therapy to Hydroxyurea to Realize Effectiveness

Status unconfirmed · Not applicable

Conditions studied: Sickle Cell Disease

In brief

This study is for caregivers of young children with sickle cell disease and adolescents with sickle cell disease who are currently prescribed hydroxyurea and are receiving care at one of the study sites. The study will assess retention and engagement during a pilot randomized control trial comparing video directly observed therapy (VDOT) to attention control. We also hope to understand more about patient and family preferences longer-term adherence monitoring and intervention. Participants will use an electronic adherence monitor (provided by the study team) to measure how often they are taking their hydroxyurea. Participants will also be asked to complete questionnaires throughout the study period to provide information about their expectations for, experience with, and satisfaction with the study materials.

Key facts

Study ID
NCT06264700
Run by
Nationwide Children's Hospital
People needed
60
Starts
2024-07-11
Expected to finish
2025-12-01
Last updated by the study team
2025-04-08

Who can join

Age: 11 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

Full record on ClinicalTrials.gov

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