VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs [IGNYTE-3]
Recruiting now · Phase 3
Conditions studied: Advanced Melanoma
In brief
This is a randomized, controlled, multicenter, open-label Phase 3 clinical study comparing VO in combination with nivolumab versus Physician's Choice treatment for patients with unresectable Stage IIIb-IV cutaneous melanoma whose disease progressed on an anti PD-1 and an anti-CTLA-4 containing regimen (administered either as a combination regimen or in sequence) or who are not candidates for treatment with an anti-CTLA-4 therapy.
Key facts
- Study ID
- NCT06264180
- Run by
- Replimune, Inc.
- People needed
- 400
- Starts
- 2024-07-11
- Expected to finish
- 2031-03-31
- Last updated by the study team
- 2026-07-15
Who can join
Age: 12 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Hackensack University Medical Center — Hackensack, New Jersey, United States (enrolling)
- The Angeles Clinic and Research Institute — Los Angeles, California, United States (enrolling)
- Banner MD Anderson Cancer Center — Gilbert, Arizona, United States (enrolling)
- Dartmouth Hitchcock Cancer Center — Lebanon, New Hampshire, United States (enrolling)
- UC Irvine Health, Chao Family Comprehensive Cancer Center — Orange, California, United States (enrolling)
- Stanford Cancer Institute — Palo Alto, California, United States (enrolling)
- USC Norris Comprehensive Cancer Center — Los Angeles, California, United States (enrolling)
- UC San Diego Moores Cancer Center — La Jolla, California, United States (enrolling)
- UCSF Helen Diller Family Comprehensive Cancer Center — San Francisco, California, United States (enrolling)
- UCLA Department of Medicine - Hematology/Oncology — Los Angeles, California, United States (enrolling)
- The Melanoma and Skin Cancer Institute — Englewood, Colorado, United States (enrolling)
- MedStar Washington Hospital Center — Washington D.C., District of Columbia, United States (enrolling)
- Memorial Cancer Institute at Memorial Regional Hospital — Hollywood, Florida, United States (enrolling)
- Baptist MD Anderson Cancer Center — Jacksonville, Florida, United States (enrolling)
- Moffitt Cancer Center — Tampa, Florida, United States (enrolling)
- Winship Cancer Institute, Emory University — Atlanta, Georgia, United States (enrolling)
- Northwestern Memorial Hospital — Chicago, Illinois, United States (enrolling)
- San Francisco Oncology Associates — San Francisco, California, United States (enrolling)
- University of Iowa — Iowa City, Iowa, United States (enrolling)
- University of Kansas Cancer Center — Westwood, Kansas, United States (enrolling)
- University of Louisville Brown Cancer Center — Louisville, Kentucky, United States (enrolling)
- University of Colorado Hospital - Anschutz Cancer Pavilion — Aurora, Colorado, United States (enrolling)
- Corewell Health — Grand Rapids, Michigan, United States (enrolling)
- University of Minnesota — Minneapolis, Minnesota, United States (enrolling)
- Morristown Medical Center - Atlantic Health System — Morristown, New Jersey, United States (enrolling)
Full record on ClinicalTrials.gov
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