Neurofrailty: A Study of Late-onset Epilepsy and Its Associations
Recruiting now
Conditions studied: Late Onset Epilepsy, Stroke, Dementia
In brief
There is not much known about why some people develop seizures in adulthood, but some researchers think that it might be a warning from the body to highlight something may be wrong with the brain. A small number of people with first seizure in adulthood go on to experience problems like stroke or dementia later in life. However, stroke and dementia are common diseases, so it is not know whether there is a real association between these conditions. When people develop their first seizure in adult life, this is sometimes called Late-Onset Epilepsy. The NeuroFrailty study, will observe 'brain health' over the years following the onset of a seizure, to provide more information about people with these kinds of seizures.
Key facts
- Study ID
- NCT06263920
- Run by
- Lancashire Teaching Hospitals NHS Foundation Trust
- People needed
- 360
- Starts
- 2022-05-05
- Expected to finish
- 2027-01-12
- Last updated by the study team
- 2025-04-08
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Exclusion criteria for case participants includes:
- a 'lesional' attributable cause for seizures including malignancy, stroke (excluding transient ischaemic attack), hypoxic brain injury, trauma, vascular or congenital abnormality of likely aetiological significance.
- people with migraine or headache syndrome can be included in case group - the presence or absence of a seizure syndrome is mutually exclusive between case and control groups, not the presence or absence of migraine.
- Exclusion criteria for control participants includes:
- diagnosis of epilepsy or confirmed seizure.
- 'lesional' attributable cause for seizures including malignancy, stroke (excluding transient ischaemic attack), hypoxic brain injury, trauma.
Where it is running
- Lancashire Teaching Hospitals NHS — Preston, Lancashire, United Kingdom (enrolling)
Full record on ClinicalTrials.gov
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