Cold and Heat Investigation to Lower Levels of Depression
Recruiting now · Not applicable
Conditions studied: Depression, Mood Disorders, Healthy (Controls)
In brief
This study will recruit 112 medically healthy adults (aged 18-65) currently experiencing depressive symptoms to be randomized to receive either a single Whole Body Hyperthermia (heat therapy) treatment or a Whole Body Hyperthermia treatment followed by a cold water plunge. Participants will complete a baseline assessment of their depressive symptoms as well as 1-week and 2-week post-treatment followup assessments.
Key facts
- Study ID
- NCT06263738
- Run by
- Barry Sandler
- People needed
- 162
- Starts
- 2024-05-14
- Expected to finish
- 2027-04-01
- Last updated by the study team
- 2025-11-13
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Individuals who currently meet study criteria for depression or individuals who do not currently meet criteria for depression
- English or Spanish speaking (able to provide informed consent and complete questionnaires in one of these languages)
- Able and willing to adhere to trial requirements, including attending all trial visits, preparatory and follow-up sessions, and completing all trial evaluations.
You may not qualify if…
- Previous adverse reaction to hypothermia, hyperthermia and/or infrared exposure
- Use of any medication that may impact thermoregulatory capacity.
- Pregnancy, active lactation, or intention to become pregnant during the study period.
- Endorses current active suicidal ideation with a plan or made a suicide attempt in the prior 6 months.
Where it is running
- Vail Health Behavioral Health Innovation Center — Edwards, Colorado, United States (enrolling)
Full record on ClinicalTrials.gov
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