Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)

Recruiting now · Not applicable

Conditions studied: Hiv

In brief

This research is being done to better understand rejection in transplant recipients with HIV who receive kidneys from donors with vs without HIV.

Key facts

Study ID

NCT06263426

Run by

Johns Hopkins University

People needed

200

Starts

2024-05-22

Expected to finish

2029-09-01

Last updated by the study team

2026-06-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participant meets local criteria for kidney transplant.
• Participant is able to understand and provide informed consent.
• Participant has documented HIV infection by any licensed assay or documented history of detectable HIV-1 RNA.
• Participant is ≥ 18 years old.
• HIV-1 RNA < 50 copies/mL. Viral blips between 50-400 copies will be allowed as long as there are not consecutive measurements > 200 copies/mL.
• Participant is not suffering from significant wasting (e.g. body mass index <21) thought to be related to HIV disease.

You may not qualify if…

• Participant has prior progressive multifocal leukoencephalopathy (PML), cryptosporidiosis of > 1 month, or primary central nervous system (CNS) lymphoma.
• Participant is pregnant or breastfeeding.
• Past or current medical problems or findings from medical history, physical examination or laboratory testing that are not listed above, which, in the opinion of the investigator, may pose additional risks from participation in the study, may interfere with the participant's ability to comply with study requirements or that may impact the quality or interpretation of the data obtained from the study.

Where it is running

• Houston Methodist Research Institute — Houston, Texas, United States (enrolling)
• University of California, Davis — Sacramento, California, United States (enrolling)
• University of California, San Diego — San Diego, California, United States (enrolling)
• University of California, San Francisco — San Francisco, California, United States (enrolling)
• Mayo Clinic Florida — Jacksonville, Florida, United States (enrolling)
• Northwestern University — Chicago, Illinois, United States (enrolling)
• Rush University Medical Center — Chicago, Illinois, United States (enrolling)
• Ochsner Clinic Foundation — New Orleans, Louisiana, United States (enrolling)
• Johns Hopkins University — Baltimore, Maryland, United States (enrolling)
• Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)
• Washington University St. Louis Barnes Jewish Hospital — St Louis, Missouri, United States (enrolling)
• New York University — New York, New York, United States (enrolling)
• Icahn School of Medicine at Mt. Sinai — New York, New York, United States (enrolling)
• Columbia University — New York, New York, United States (enrolling)
• University of Alabama at Birmingham — Birmingham, Alabama, United States (enrolling)
• University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)
• University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States (enrolling)
• Weill Cornell Medical Center — New York, New York, United States

Full record on ClinicalTrials.gov

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