A Study to Assess and Compare Safety and Tolerability of 3 Months Treatment With Salbutamol Administered Via MDI Containing Propellant HFA-152a or HFA-134a in Participants ≥ 18 Years of Age With Asthma

Completed · Phase 3

Conditions studied: Asthma

In brief

The goal of this study is to assess and compare the safety and tolerability of salbutamol administered via metered dose inhaler (MDI) containing propellant 1,1-difluoroethane (HFA-152a) or 1,1,1,2-tetrafluoroethane (HFA-134a) in participants aged \>=18 years with asthma

Key facts

Study ID: NCT06261957
Run by: GlaxoSmithKline
People needed: 477
Starts: 2024-05-31
Expected to finish: 2025-09-02
Last updated by the study team: 2026-02-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Participant of ≥18 years of age at the time of signing the informed consent or written informed consent is obtained from each study participant's legal guardian.
Asthma for ≥ 6 months, defined as:
Documented history of asthma, as defined by Global Initiative for Asthma (GINA) (GINA, 2023]
Receiving one of the following asthma treatments, at a stable dose (applicable to daily Inhaled corticosteroid (ICS), ICS/Long-acting bronchodilator (LABA), and ICS/LABA/Long-acting muscarinic antagonist [LAMA]), for at least 12 weeks prior to the screening visit, with treatment that is anticipated to remain stable for the duration of the study:
Short-Acting Beta-2-Adrenoreceptor Agonists (SABA) used as needed for asthma symptoms
Daily maintenance low to medium dose Inhaled corticosteroid (ICS) (low to medium dose ICS defined as 100-500 μg/day fluticasone propionate or equivalent as defined in the 2023 GINA guidelines [GINA, 2023], plus Short-Acting Beta-2-Adrenoreceptor Agonists (SABA), which is anticipated to remain stable for the duration of the study.
Daily maintenance low to medium dose ICS/ Long-acting bronchodilator (LABA) (low to medium dose ICS defined as 100-500 μg/day fluticasone propionate or equivalent as defined in the GINA guidelines [GINA, 2023] plus SABA, which is anticipated to remain stable for the duration of the study.
Daily maintenance ICS/LABA/LAMA (low to medium dose ICS defined as 100-500 µg/day fluticasone propionate or equivalent as defined in the GINA guidelines [GINA, 2023] plus SABA, which is anticipated to remain stable for the duration of the study.
Participants who utilize combination budesonide/formoterol as reliever therapy, whether or not this is in addition to a SABA - are not eligible for screening.
Participants who utilize ICS/SABA combination therapy as reliever therapy, in addition to low to medium dose ICS or ICS/LABA as maintenance, are only eligible if they agree to discontinue their ICS/SABA inhaler for the duration of the study (screening through follow-up).
Severity of disease assessed by the investigator by baseline pre-bronchodilator Forced expiratory volume in 1 second (FEV1)
Asthma Control Status
Asthma Control Questionnaire (ACQ) 6 score <1.5 at screening
Asthma that has remained stable with no severe exacerbations in the last 6 months. Severe exacerbation defined as:
Deterioration of asthma-requiring the use of systemic corticosteroids (tablets, suspension or injection), for at least 3 days, OR
An inpatient hospitalization or Emergency Department (ED) visit because of asthma, requiring systemic corticosteroids.
Evidence of reversibility of disease: Airway reversibility is defined as ≥12 percent (%) and ≥200 milliliter (mL) increase in FEV1 within 20 to 60 minutes following up to 4 inhalations of albuterol/salbutamol aerosol.
Participants on as-needed SABA only, or daily maintenance ICS (plus as needed SABA):
With a documented history of reversibility (as defined above) within 2 years will meet this inclusion criterion. Pre- and post-bronchodilator measurements will still be collected at screening to characterize the degree of reversibility.
Who do not have a documented history of reversibility within the past 2 years will need to demonstrate reversibility during the screening period.
SABA should be withheld for ≥6 hours
Participants on daily maintenance ICS/LABA or ICS/LABA/LAMA:
Participants on daily maintenance ICS/LABA or ICS/LABA/LAMA:
Do not need to demonstrate reversibility in accordance with the above definition during the screening period. A reversibility maneuver will be performed to characterize the degree of post-bronchodilator change.
SABA should be withheld for ≥6 hours

You may not qualify if…

A history of life-threatening asthma or asthma that is unstable in the opinion of the investigator.
Other significant pulmonary diseases to include (but not limited to): pneumothorax, pulmonary fibrotic disease, bronchopulmonary dysplasia, chronic bronchitis, emphysema, chronic obstructive pulmonary disease, tuberculosis or other respiratory abnormalities other than asthma.
Respiratory Infection: Culture-documented or suspected bacterial or viral infection of the upper or lower respiratory tract, sinus or middle ear that is not resolved within 4 weeks of screening that led to a change in asthma management, OR in the opinion of the Investigator, is expected to affect the participant's asthma status, OR the participant's ability to participate in the study.
Asthma Exacerbation: Any severe asthma exacerbation within 6 months prior to screening.
Current or chronic history of liver disease or known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones) Biologic/immunosuppressive therapies used for the treatment of respiratory diseases during the 6 months, or 5 half-lives-whichever is longer-prior to start of the study.

Where it is running

GSK Investigational Site — San Mateo, California, United States
GSK Investigational Site — Aventura, Florida, United States
GSK Investigational Site — Clearwater, Florida, United States
GSK Investigational Site — DeLand, Florida, United States
GSK Investigational Site — Miami, Florida, United States
GSK Investigational Site — Miami, Florida, United States
GSK Investigational Site — Miami, Florida, United States
GSK Investigational Site — Naples, Florida, United States
GSK Investigational Site — Plantation, Florida, United States
GSK Investigational Site — Winter Park, Florida, United States
GSK Investigational Site — Rincon, Georgia, United States
GSK Investigational Site — Stonecrest, Georgia, United States
GSK Investigational Site — Louisville, Kentucky, United States
GSK Investigational Site — Owensboro, Kentucky, United States
GSK Investigational Site — Fall River, Massachusetts, United States
GSK Investigational Site — Minneapolis, Minnesota, United States
GSK Investigational Site — Minneota, Minnesota, United States
GSK Investigational Site — Olive Branch, Mississippi, United States
GSK Investigational Site — Columbia, Missouri, United States
GSK Investigational Site — Henderson, Nevada, United States
GSK Investigational Site — Jersey City, New Jersey, United States
GSK Investigational Site — Riverdale, New Jersey, United States
GSK Investigational Site — Brooklyn, New York, United States
GSK Investigational Site — Asheville, North Carolina, United States
GSK Investigational Site — North Hollywood, California, United States

Full record on ClinicalTrials.gov

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