A Comprehensive Evaluation of Tobacco-Flavored vs. Non-Tobacco Flavored E-cigarettes on Smoking Behavior

Recruiting now · Not applicable

Conditions studied: Cigarette Smoking-Related Carcinoma

In brief

This clinical trial compares the use of tobacco flavored electronic cigarettes (ECs) vs. non-tobacco flavored ECs vs. nicotine replacement therapy (patches and lozenges) on smoking behavior in current cigarette smokers. ECs may reduce cigarette craving and withdrawal symptoms, increase motivation and confidence to stop cigarette smoking, and decrease cigarette smoking and dependence. By comparing participants' preferred flavor ECs (PEC) to tobacco flavor ECs (TEC) to NRT, researchers hope to determine the effect of EC flavors on appeal and use and learn how ECs affect smoking behaviors and health.

Key facts

Study ID

NCT06260683

Run by

Ohio State University Comprehensive Cancer Center

People needed

1500

Starts

2024-04-10

Expected to finish

2028-04-12

Last updated by the study team

2026-04-06

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• >= 21 years old
• Smoke >= 5 cigarettes per day for the past year
• Willing to use either an EC or NRT
• Read and speak English
• Have a smartphone

You may not qualify if…

• Report currently using smoking cessation medications, NRT, or actively seeking treatment for smoking cessation
• Current use of an EC > 4 days a month
• Diagnosed medical conditions of lung disease, asthma, cystic fibrosis, heart disease or chronic obstructive pulmonary disease (COPD)
• Unmanaged (unmedicated and/or without counseling) diagnosis of schizophrenia
• History of cardiac event or distress within the past 3 months
• Currently pregnant, planning to become pregnant within 6 months, or breastfeeding
• High blood pressure not controlled by medications
• Serious angina pectoris or chest pain
• Stroke within the past three months
• Known allergy to propylene glycol or vegetable glycerin
• Serious underlying arrhythmias, irregular heartbeat or abnormal heart rhythm
• Live in same household as another study participant

Where it is running

• Ohio State University Comprehensive Cancer Center — Columbus, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.