Function of Tamsulosin in Older Males Undergoing Surgery With Indwelling Catheter
Completed · Phase 3
Conditions studied: Postoperative Urinary Tract Infection
In brief
This study is being done to answer the question: What is the impact of a medication called tamsulosin (also called Flomax) on the rate of postoperative urinary retention (POUR) and catheter-associated urinary tract infection (UTI)? One of the most common complications following surgery and associated with Foley catheters is post-operative urinary retention (POUR) after the catheter is removed. This is defined as being unable to urinate spontaneously within 8 hours following the removal of the indwelling Foley catheter (the catheter that sits in your bladder to drain urine after surgery). When this happens, it requires intermittent straight catheterization of the bladder (placing a temporary catheter in the bladder to drain the buildup of urine), which can cause a lot of discomfort and anxiety, as well as increase the risk of catheter-associated urinary tract infection (CAUTI).
Key facts
- Study ID
- NCT06257576
- Run by
- Emory University
- People needed
- 87
- Starts
- 2024-02-26
- Expected to finish
- 2025-11-12
- Last updated by the study team
- 2026-04-09
Who can join
Age: 50 and older. Sex: male. Healthy volunteers: not accepted.
You may qualify if…
- Planned for elective surgery for any reason (benign, malignant, or indeterminate lesion) with either an open or minimally invasive approach (hepatobiliary, pancreatic, and colorectal operations)
- Male and age ≥50 years
- Deemed physically fit for surgery
You may not qualify if…
- Inability to obtain informed consent
- Age <50 years
- Female
- Baseline creatinine >1.5x upper limit of normal
- Tamsulosin therapy as a home-medication
- Procedure involving the prostate, bladder, ureters, or kidneys
- Planned Foley catheter removal on the same day of surgery
- Planned nasogastric tube retention on postoperative day 1
- Individuals taking daily phosphodiesterase 5 (PDE5) inhibitors (due to the risk of symptomatic hypotension if given with tamsulosin)
Where it is running
- Emory Saint Joseph's Hospital — Atlanta, Georgia, United States
- Emory University Hospital Midtown — Atlanta, Georgia, United States
- Emory University Hospital (EUH) — Atlanta, Georgia, United States
- Emory Johns Creek Hospital — Johns Creek, Georgia, United States
Full record on ClinicalTrials.gov
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