Ventricular Arrhythmias in Patients Undergoing Mitral Valve Surgery
Recruiting now
Conditions studied: Mitral Regurgitation, Mitral Valve Prolapse, Ventricular Tachycardia
In brief
Study objectives: * To assess the impact of mitral valve surgery for mitral regurgitation on ventricular arrhythmic burden and surrogate markers of fibrosis in patients with arrhytmogenic mitral valve prolapse (MVP) from baseline to 6 months after surgery * To characterize the molecular landscape of arrhytmogenic MVP Study design: -Prospective explorative observational study Study population: -90 patients with arrhytmogenic MVP and without arrhytmogenic MVP (controls) eligible for mitral valve surgery for mitral regurgitation will be enrolled. All patients will be evaluated with cardiac magnetic resonance (CMR) imaging and continuous seven day arrhythmic monitoring before and at 6 months after mitral valve surgery
Key facts
- Study ID
- NCT06255457
- Run by
- Karolinska Institutet
- People needed
- 90
- Starts
- 2024-02-21
- Expected to finish
- 2026-03-01
- Last updated by the study team
- 2025-09-11
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18 and over
- Patients with and without (controls) arrhythmogenic MVP in need of mitral valve surgery for primary mitral regurgitation according to current standard of care
You may not qualify if…
- Secondary mitral regurgitation
- Primary mitral regurgitation not due to degenerative disease (including rheumatic disease)
- Co-existing moderate or severe aortic valve disease
- Congenital heart disease
- Inherited or acquired cardiomyopathy
- Non-incidental or symptomatic coronary artery disease
- Uncontrolled atrial fibrillation (resting heart rate > 100/min)
- Pregnancy
- Unable to undergo CMR
Where it is running
- Karolinska Univeristy Hospital — Stockholm, Stockholm County, Sweden (enrolling)
Full record on ClinicalTrials.gov
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