Precision Resuscitation With Crystalloids in Sepsis

Completed · Not applicable

Conditions studied: Sepsis

In brief

Fluids are one of the most common treatments given to patients in the hospital. Fluids are especially important in treating patients with sepsis. Multiple clinical studies have compared the two main types of fluids used in sepsis (normal saline and balanced crystalloids). However, these studies have not found a clear benefit of one type of fluid versus the other. Which fluid should be given to which patient is an essential question because of the ubiquity of this intervention. Even a small difference in mortality could drastically change the standards of care given the national (and worldwide) scale of this intervention. The investigators have developed an algorithm that uses bedside vital signs (temperature, heart rate, respiratory rate, and blood pressure) to identify a group of patients (Group D) who have a significant mortality benefit from balanced crystalloids. The study randomizes adult patients admitted through emergency departments across 6 Emory hospitals belonging to Group D to intervention versus usual care. The intervention arm involves a prompt to clinicians to use balanced crystalloids rather than normal saline.

Key facts

Study ID

NCT06253585

Run by

Emory University

People needed

2012

Starts

2024-06-13

Expected to finish

2025-12-19

Last updated by the study team

2026-03-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All adult patients presenting to the Emergency Department, with a blood culture order in the Emergency Department, who are classified as Group D, in whom a clinician initiates a normal saline order

You may not qualify if…

• None

Where it is running

• Emory Midtown Hospital — Atlanta, Georgia, United States
• Emory Saint Joseph's Hospital — Atlanta, Georgia, United States
• Emory Healthcare System — Atlanta, Georgia, United States
• Emory Hospital — Atlanta, Georgia, United States
• Emory Decatur Hospital — Decatur, Georgia, United States
• Emory Johns Creek Hospital — Johns Creek, Georgia, United States
• Emory Hillandale Hospital — Lithonia, Georgia, United States

Full record on ClinicalTrials.gov

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