Continuous Infusion of Norepinephrine vs Phenylephrine During Spinal Anesthesia for Cesarean Section (INPEACE)

Recruiting now · Phase 4

Conditions studied: Cesarean Section Complications, Hypotension

In brief

The goal of this clinical trial is to compare norepinephrine and ephedrine in maintaining blood pressure during spinal anaesthesia for elective cesarean delivery. The main questions it aims to answer are: * Do phenylephrine and norepinephrine administered as manually controlled continuous infusion during elective cesarean delivery have different effects on neonatal outcome ? * Do phenylephrine and norepinephrine administered as manually controlled continuous infusion during elective cesarean delivery have different effects on maternal hemodynamics? Participants will receive either phenylephrine or norepinephrine infusion, at the time of performing spinal anesthesia, the infusion rate will be adjusted manually depending on maternal arterial pressure.

Key facts

Study ID: NCT06248593
Run by: Hassan II University
People needed: 140
Starts: 2025-01-29
Expected to finish: 2026-03-15
Last updated by the study team: 2025-09-09

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

Full-term, singleton, pregnant women, nonlaboring.
Scheduled for elective cesarean delivery under spinal anesthesia,
American Society of Anesthesiologists physical status : 1 or 2
Baseline systolic BP between 90 and 140 mm Hg.

You may not qualify if…

Known fetal abnormality.
Preexisting or pregnancy-induced hypertension, cardiovascular, cerebrovascular or kidney disease.
Contraindication to spinal anesthesia.
Peripartum hemorrhage.
Body mass index above 40 kg/m2.

Where it is running

University hospital Hassan II — Fes, Morocco (enrolling)
University hospital Hassan II — Fes, Morocco

Full record on ClinicalTrials.gov

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