NIBS Therapy in Subacute Spinal Cord Injury
Enrolling by invitation · Not applicable · Has a placebo group
Conditions studied: Traumatic Spinal Cord Injury, Tetraplegia/Tetraparesis
In brief
No accepted clinical therapies exist for repair of motor pathways following spinal cord injury (SCI) in humans, leaving permanent disability and devastating personal and socioeconomic cost. A robust neural repair strategy has been demonstrated in preclinical studies, that is ready for translation to recovery of hand and arm function in human SCI, comprising daily transcranial magnetic stimulation treatment at the inpatient rehabilitation facility. This study will establish clinical effect size of the intervention, as well as safety and feasibility necessary for a subsequent controlled efficacy trial and inform preclinical studies for dosing optimization.
Key facts
- Study ID
- NCT06247904
- Run by
- Albert Einstein Healthcare Network
- People needed
- 20
- Starts
- 2025-04-09
- Expected to finish
- 2026-05-31
- Last updated by the study team
- 2025-04-30
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Post traumatic or non-traumatic cervical spinal cord injury (SCI) with residual upper-extremity paralysis
- Time post-injury less than six weeks
- Neurological Level of Injury (NLI) C4-C6
- ASIA Impairment Scale (AIS) A-D
- Sensory and motor zone of partial preservation (ZPP, clinically complete or incomplete)
- Age 18 to 80 years old
You may not qualify if…
- Ventilator dependence;
- Concurrent neurological condition affecting sensory or motor pathways or otherwise limiting ability to participate in the study;
- Evidence of trauma-related brain injury;
- Contraindications for TMS or history of seizure or seizure risk;
- Spinal instability;
- Uncontrolled autonomic dysreflexia;
- Severe muscular or skeletal or neuropathic pain;
- Known or suspected pregnancy;
- Medically unstable or any reason the physician may deem as inappropriate for the participant to enroll or continue in the study.
Where it is running
- Jefferson Moss-Magee Rehabilitation - Elkins Park — Elkins Park, Pennsylvania, United States
Full record on ClinicalTrials.gov
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