Ibuprofen and Biomarkers of Acute Kidney Injury After Running in the Heat

Completed · Phase 1 · Has a placebo group

Conditions studied: Acute Kidney Injury

In brief

The goal of this study is to determine if ibuprofen prior to exercise in the heat worsens biomarkers of acute kidney injury. Participants were given 600mg of ibuprofen or placebo (corn starch) 12- and 1-hour prior to running for 1-hour in a hot environment (35°C) at moderate intensity. Urine, plasma, and serum samples were collected pre-, post-, and 1hour post-exercise to assess biomarkers of acute kidney injury. This was a double blind, randomized crossover design, so that participants completed the alternate trial (ibuprofen or placebo) at least seven days later.

Key facts

Study ID

NCT06247462

Run by

University of New Mexico

People needed

12

Starts

2023-06-01

Expected to finish

2023-09-05

Last updated by the study team

2026-01-26

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Physically active (engage in at least 150 minutes of moderate to vigorous intensity exercise per week)
• between the ages of 18 and 45
• Able to run continuously for at least 60 minutes
• Able to speak and read English.

You may not qualify if…

• Non-English speakers, prisoners, pregnant women, or persons requiring a LAR
• Previous history of heat stroke or heat illness
• Currently experiencing a sunburn or other burn injury
• Have repeated exposure to heat, such as hot baths, sauna, or travel to a hot environment
• Has resided in a hot climate within 2 months prior to the trial
• Answered "yes" to at least one question on the physical activity readiness questionnaire
• Shows signs or symptoms of or are known to have cardiovascular, renal, metabolic, or pulmonary disease as determined by a health questionnaire
• Are a current smoker
• History of regular gastrointestinal distress
• Known history of stomach ulcers or taking blood thinning medication
• Known allergy to ibuprofen
• Have a resting blood pressure greater than 140 systolic or 90 diastolic
• Do not engage in at least 150 minutes of moderate to vigorous intensity exercise per week.

Where it is running

• Exercise Physiology Lab — Albuquerque, New Mexico, United States

Full record on ClinicalTrials.gov

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