Physiologic Pacing for Symptomatic First-Degree Heart Block

Status unconfirmed · Not applicable

Conditions studied: Symptomatic First-degree Heart Block

In brief

The purpose of this study is to determine if physiologic pacing will improve symptoms and outcomes in patients with symptomatic first-degree heart block (pr interval ≥250ms).

Key facts

Study ID

NCT06245304

Run by

Ascension Health

People needed

40

Starts

2023-10-01

Expected to finish

2025-06-30

Last updated by the study team

2024-02-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged 18 or above
• Ventricular Ejection Fraction (EF) > 50%
• New York Heart Association (NYHA) class II-IV
• PR interval ≥250ms
• Narrow QRS duration (≤140ms) or prolonged QRS duration with typical Right Bundle Branch Block (RBBB) morphology on 12 lead ECG and sinus rhythm

You may not qualify if…

• Permanent atrial fibrillation (AF)
• Patients who are unable to perform a 6 minute hall walk
• Other serious medical condition with life expectancy of less than 1 year
• Lack of capacity to consent
• Pregnancy
• Contraindication to use of the relevant study device or leads (as per current manuals from manufacturer)

Where it is running

• Ascension Saint Thomas Midtown — Nashville, Tennessee, United States (enrolling)

Full record on ClinicalTrials.gov

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