Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis

Recruiting now · Phase 4 · Has a placebo group

Conditions studied: Knee Osteoarthritis

In brief

This is a clinical trial of people who have pain due to knee osteoarthritis at Northwestern University Feinberg School of Medicine. The study will last for about 20 weeks. 180 qualified participants will be randomly assigned in a 1:1:1 ratio (60 participants per group) to one of three treatment groups: duloxetine, celecoxib, or placebo. Participants will have a knee Xray, (optional) MRIs of the brain and knee, blood draws, pain sensitivity testing, and asked to fill out questionnaires. The purpose of this study is to try to predict which participants will respond to the treatment.

Key facts

Study ID

NCT06245109

Run by

Northwestern University

People needed

180

Starts

2024-02-26

Expected to finish

2028-03-15

Last updated by the study team

2026-04-30

Who can join

Age: 41 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female, age greater than 40 years, with no racial/ethnic restrictions;
• Meet American College of Radiology criteria for knee osteoarthritis (OA) based on radiographic evidence;
• Knee pain most days of the week for the past month at screening;
• Must have average pain score for the week prior to baseline of ≥ 4.0 (on a 0 to 10 Numeric Rating Scale)
• Must complete pain ratings on at least 4 out of 7 days prior to baseline;
• Must be able to read and speak English and be willing to read and understand instructions as well as questionnaires;
• Must be in generally stable health;
• Must be able to return for all clinic visits;
• Willing to remain stable on any concomitant therapies (Transcutaneous Electrical Nerve Stimulation (TENS) unit, ice, glucosamine chondroitin, cannabinoids, etc.);
• Must sign an informed consent document after complete explanation of the study documenting that they understand the purpose of the study, procedures to be undertaken, possible benefits, potential risks, and are willing to participate;
• Ambulatory with or without a cane, brace(s), or walking stick (use of walker or wheelchair will be exclusionary);
• Glucagon-like peptide 1 (GLP-1) agonists or other weight-loss treatment permitted if started more than 3 months prior to screening with no significant change in weight (+/- 11 lbs) over the past 30 days;

You may not qualify if…

• Evidence of rheumatoid arthritis, ankylosing spondylitis, other inflammatory arthropathy;
• Functional class IV congestive heart failure;
• Significant other medical disease such as uncontrolled hypertension, untreated diabetes mellitus, coronary or peripheral vascular disease, chronic obstructive lung disease, or liver disease (liver function tests > upper limit of normal);
• Current use of illicit drugs or history (in last 12 months) of alcohol or drug abuse;
• Current cannabinoid use for knee pain;
• High dose opioid use, as defined as > 50mg morphine equivalent/day;
• Any medical condition that in the investigator's judgment may prevent the individual from completing the study or put the individual at undue risk;
• In the judgment of the investigator, unable or unwilling to follow protocol and instructions;
• Intra-axial implants (e.g., spinal cord stimulators or pumps);
• Currently breastfeeding, pregnant, or planning to become pregnant during the study;
• Chronic neurologic conditions, e.g., Parkinson's;
• Renal insufficiency (creatinine >1.5 mg/dl);
• Previous history of peptic ulcer or gastrointestinal bleeding;
• Current use of anticoagulants or platelet inhibitors other than aspirin at ≤325 mg/day;
• Allergy to sulfonamide drugs, duloxetine, nonsteroidal anti-inflammatory drugs (NSAIDs), or acetaminophen;
• Acute myocardial infarction or coronary artery bypass graft surgery, in the past 12 months;
• Recent injection into the index knee of hyaluronic acid or other substance in the last 6 months, or steroid in the last 90 days;
• Lactose allergy;
• Current use of selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and/or tricyclic antidepressants (TCAs) at a therapeutic dose. Occasional use of these medications as a sleep aid will be allowed; however, participants will need to agree to remain on a stable dose of the medication while in the study;
• Uncontrolled narrow-angle glaucoma;
• Malignancy within 2 years of screening, with the exception of squamous cell carcinoma, basal cell carcinoma and prostate cancer (grade group 1);
• Active treatment for cancer other than superficial skin cancer; or
• Nerve ablation performed on the index knee within 12 months of screening.

Where it is running

• Northwestern University — Chicago, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

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