Evaluating Process of Change in Cognitive Behavioral Therapy and Acceptance and Commitment Therapy for Depression

Completed · Not applicable

Conditions studied: Depression

In brief

This study will compare two psychological treatments for major depressive disorder (MDD): cognitive-behavioral therapy (CBT) and acceptance and commitment therapy (ACT). Both treatments are well-studied and supported by evidence as effective options for people experiencing depression. These treatments will be delivered in an online group format via Zoom. The study will enroll up to 100 participants with depression. Half of the participants will receive online group CBT and half will receive online group ACT. There will be up to 10 members in each group. For both conditions, treatment will be provided over 8 weeks, with a 6-month follow-up period. Enrollment will be ongoing and groups will occur simultaneously. Potential participants are asked to complete an initial screening and an intake evaluation to determine eligibility. They will then receive 8-weeks of treatment. Participants will complete self-report questionnaires throughout their time in the study.

Key facts

Study ID

NCT06245096

Run by

University of Southern California

People needed

116

Starts

2024-02-14

Expected to finish

2026-04-29

Last updated by the study team

2026-05-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• diagnosis of major depressive disorder (MDD) according to DSM-V criteria (APA, 2013)
• 18 years of age or older
• access to a private location with a stable internet connection and a working video camera
• lives in California
• able to understand and speak English
• able and willing to give informed consent

You may not qualify if…

• current diagnosis other than MDD if it constitutes the predominant aspect of the clinical presentation and if it requires treatment other than that being offered
• clear indication of secondary gain (e.g., court ordered treatment)
• current suicide risk or significant intentional self-harm in the last six months sufficient to preclude treatment on an outpatient basis.

Where it is running

• University of Southern California — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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