A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab on Background Topical Corticosteroids Therapy in Participants Aged 12 Years and Older With Moderate-to-severe AD Who Have Had an Inadequate Response to Prior Biologic Therapy or an Oral JAK Inhibitor

Recruiting now · Phase 3 · Has a placebo group

Conditions studied: Dermatitis Atopic

In brief

This is a parallel group, Phase 3, multinational, multicenter, randomized, double-blind, placebo-controlled, 3-arm study for treatment of participants diagnosed with moderate-to-severe AD on background TCS who have had inadequate response to prior biologic or oral JAKi therapy. The purpose of this study is to measure the efficacy and safety of treatment with amlitelimab solution for subcutaneous (SC) injection compared with placebo in participants with moderate-to-severe AD aged 12 years and older on background TCS and have had an inadequate response to prior biologic or an oral JAKi therapy. Study details include: At the end of the treatment period, participants will have the option to enter the Long-Term Safety Study LTS17367 (RIVER-AD). The study duration will be up to 56 weeks for participants not entering the long-term safety study (LTS17367 \[RIVER-AD\]) including a 2 to 4-week screening, a 36-week randomized double-blind period, and a 16-week safety follow-up. The study duration will be up to 40 weeks for participants entering the long-term safety study (LTS17367 \[RIVER-AD\]) including a 2 to 4-week screening and a 36-week randomized double-blind period. The total treatment duration will be up to 36 weeks. The total number of visits will be up to 13 visits (or 12 visits for those entering the long-term safety study LTS17367 \[RIVER-AD\] study).

Key facts

Study ID

NCT06241118

Run by

Sanofi

People needed

636

Starts

2024-02-29

Expected to finish

2028-09-29

Last updated by the study team

2026-07-02

Who can join

Age: 12 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants must be 12 years of age (when signing informed consent form)
• Diagnosis of AD for at least 1 year (defined by the American Academy of Dermatology Consensus Criteria)
• Documented history prior to screening visit of inadequate response to a biologic AD medication or an oral JAKi therapy.
• v-IGA-AD of 3 or 4 at baseline visit
• EASI score of 16 or higher at baseline
• AD involvement of 10% or more of BSA at baseline
• Weekly average of daily PP-NRS of ≥ 4 at baseline visit.
• Able and willing to comply with requested study visits and procedures
• Body weight ≥25 kg

You may not qualify if…

• Participants are excluded from the study if any of the following criteria apply:
• Skin co-morbidity that would adversely affect the ability to undertake AD assessments
• Known history of or suspected significant current immunosuppression
• Any malignancies or history of malignancies prior to baseline (with the exception of non-melanoma skin cancer excised and cured >5 years prior to baseline)
• History of solid organ or stem cell transplant
• Any active or chronic infection including helminthic infection requiring systemic treatment within 4 weeks prior to baseline
• Positive for human immunodeficiency virus (HIV), Hepatitis B or hepatitis C at screening visit
• Having active tuberculosis (TB), latent TB, a history of incompletely treated TB, suspected extrapulmonary TB infection, or who are at high risk of contracting TB
• Having received any of the specified therapy within the specified timeframe(s) prior to the baseline visit
• In the Investigator's opinion, any clinically significant laboratory results or protocol specified laboratory abnormalities at screening
• History of hypersensitivity or allergy to any of the excipients or investigational medicinal product (IMP)
• The above information is not intended to contain all considerations relevant to a potential participation in a clinical trial

Where it is running

• Center for Dermatology and Plastic Surgery- Site Number : 8401119 — Scottsdale, Arizona, United States (enrolling)
• Arkansas Dermatology - North Little Rock- Site Number : 8401244 — North Little Rock, Arkansas, United States (enrolling)
• Encino Research Center- Site Number : 8401042 — Encino, California, United States (enrolling)
• Center for Dermatology Clinical Research- Site Number : 8401018 — Fremont, California, United States (enrolling)
• Long Beach Clinical Trials- Site Number : 8401188 — Long Beach, California, United States (enrolling)
• Dermatology Research Associates - Los Angeles- Site Number : 8401092 — Los Angeles, California, United States (enrolling)
• LA Universal Research Center- Site Number : 8401064 — Los Angeles, California, United States (enrolling)
• University Dermatology Trials- Site Number : 8401339 — Newport Beach, California, United States (enrolling)
• Rady Children's Hospital- Site Number : 8401291 — San Diego, California, United States (enrolling)
• Therapeutics Clinical Research- Site Number : 8401283 — San Diego, California, United States (enrolling)
• Paradigm Clinical Research - Wheat Ridge- Site Number : 8401245 — Wheat Ridge, Colorado, United States (enrolling)
• Encore Medical Research of Boynton Beach- Site Number : 8401030 — Boynton Beach, Florida, United States (enrolling)
• St. Jude Clinical Research- Site Number : 8401287 — Doral, Florida, United States (enrolling)
• Apex Clinical Research - Jacksonville- Site Number : 8401332 — Jacksonville, Florida, United States (enrolling)
• Clever Medical Research- Site Number : 8401160 — Miami, Florida, United States (enrolling)
• Global Clinical Professionals (GCP)- Site Number : 8401045 — St. Petersburg, Florida, United States (enrolling)
• Avita Clinical Research- Site Number : 8401073 — Tampa, Florida, United States (enrolling)
• Northwestern University- Site Number : 8401285 — Chicago, Illinois, United States (enrolling)
• NorthShore University Health System - Endeavor Health Medical Group - Skokie - Woods Drive- Site Number : 8401038 — Skokie, Illinois, United States (enrolling)
• Dawes Fretzin Clinical Research- Site Number : 8401015 — Indianapolis, Indiana, United States (enrolling)
• Equity Medical - Bowling Green- Site Number : 8401296 — Bowling Green, Kentucky, United States (enrolling)
• Tandem Clinical Research - Metairie- Site Number : 8401187 — Metairie, Louisiana, United States (enrolling)
• University of Michigan Health System - Ann Arbor- Site Number : 8401290 — Ann Arbor, Michigan, United States (enrolling)
• MI Skin Center- Site Number : 8401307 — Northville, Michigan, United States (enrolling)
• University of Alabama at Birmingham- Site Number : 8401267 — Birmingham, Alabama, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.