REGN5381 in Adult Participants With Heart Failure With Reduced Ejection Fraction
Stopped early · Phase 2 · Has a placebo group
Conditions studied: Heart Failure
In brief
This study is researching an experimental drug called REGN5381 (called "study drug"). The study is focused on patients with heart failure with reduced ejection fraction (ie, the heart is not functioning as well as it should). The aim of the study is to see how safe, tolerable, and effective the study drug is. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the study drug less effective or could lead to side effects)
Key facts
- Study ID
- NCT06237309
- Run by
- Regeneron Pharmaceuticals
- People needed
- 89
- Starts
- 2024-04-11
- Expected to finish
- 2025-12-29
- Last updated by the study team
- 2026-01-14
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Arensia Exploratory Medicine Clinic — Phoenix, Arizona, United States
- Harbor UCLA Medical Center — Torrance, California, United States
- Flourish Research - Miami (Kendall) (Formerly Clinical Site Partners) — Miami, Florida, United States
- Flourish Research - Orlando (Formerly Clinical Site Partners) — Winter Park, Florida, United States
- Grand Hopital de Charleroi — Gilly, Hainaut, Belgium
- Anima Research Center — Alken, Limburg, Belgium
- Onze Lieve Vrouw Ziekenhuis Aalst — Aalst, Oost-Vlaanderen, Belgium
- UZ Leuven — Leuven, Vlaams Brabant, Belgium
- Algemeen Ziekenhuis St Jan Brugge Oostende Av — Bruges, West Flanders, Belgium
- Algemeen Ziekenhuis Groeninge — Kortrijk, West Vlaanderen, Belgium
- AZ Oostende — Ostend, West Vlaanderen, Belgium
- Centre Hospitalier Regional de la Citadelle — Liège, Belgium
- MHAT Haskovo — Haskovo, Bulgaria
- University Multiprofile Hospital for Active Treatment Plovdiv — Plovdiv, Bulgaria
- Arensia Exploratory Medicine Clinic at MBAL Sveta Sofia — Sofia, Bulgaria
- Fakultni Nemocnice v Motole — Prague, Central Bohemian, Czechia
- University Hospital Brno — Brno, South Moravian, Czechia
- Medicus Services s.r.o. — Brandýs nad Labem-Stará Boleslav, Czechia
- Edumed — Jaroměř, Czechia
- Arensia Exploratory Medicine at the Research Institute of Clinical Medicine — Tbilisi, Georgia
- First Cardiology Clinic University of Athens — Athens, Attica, Greece
- Athens Naval Hospital — Athens, Attikh, Greece
- General University Hospital Attikon — Chaïdári, Greece
- Larissa University Hospital — Larissa, Greece
- Pmsi Republican Clinical Hospital Timofei Mosneaga — Chisinau, Moldova
Full record on ClinicalTrials.gov
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