Effects of Goji vs. Fiber on Macular Degeneration

Recruiting now · Not applicable

Conditions studied: Age-Related Macular Degeneration

In brief

The goal of this project is to conduct a clinical trial in 60 participants ranging from age 65-95 who are at risk for age-related macular degeneration (AMD). The study will evaluate the effects of 14g of goji berry intake or an equivalent amount and type of fiber, five days a week for six months, on visual health, gut microbiome profiles, skin carotenoid measures, and lipoprotein profiles.

Key facts

Study ID

NCT06237127

Run by

University of California, Davis

People needed

60

Starts

2024-04-29

Expected to finish

2027-12-31

Last updated by the study team

2026-07-17

Who can join

Age: 65 and older, up to 95. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Family history of AMD
• Hyperlipidemia or managed diabetes
• 65 - 95 years of age

You may not qualify if…

• Dislike of, or allergy to, goji berries or any of the ingredients in the fiber-rich wafers and gummies (wheat, corn, oats, soy, natural orange flavor, xylitol, annatto, pectin, or other food ingredients)
• Consumption of > 2 alcoholic drinks per day
• Indications of substance or alcohol abuse
• Current or planned use of a blood thinner (e.g., Coumadin, Warfarin) at any time during study
• Use of multi-vitamin or any other supplements that contain lutein and/or zeaxanthin (if willing to stop the supplement, subject can be enrolled 6 months from stop date)
• Taking any new medications started within the past 6 months, or changes in medication regimen planned in the next 6 months (stable use greater than 6 months is not exclusionary)
• Any planned international travel during the study
• Consuming >3 servings/day of a combination of spinach, kale, lettuce, orange bell peppers, corn, parsley, squash, broccoli, pumpkin, edamame
• Regularly consuming >3 eggs/day
• Currently participating in any other interventional research study
• Diagnosed with inflammatory bowel disease, irritable bowel syndrome, other gastrointestinal disorder, undergoing cancer therapy or immunocompromised, or diagnosis of another condition where lutein, zeaxanthin and/or fiber supplementation would be contraindicated or would interfere with ability to participate in the study
• Any physical characteristic or condition that precludes ability to perform study procedures
• Medical or psychiatric condition that, in the opinion of the Investigator, would compromise study findings or prevent the participant from completing the study

Where it is running

• UC Davis Eye Center, Tschannen Eye Institute — Sacramento, California, United States (enrolling)

Full record on ClinicalTrials.gov

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