Remifentanil Effect on Burst Suppression Ratio
Recruiting now · Not applicable
Conditions studied: Anesthesia, Intravenous, Electroencephalography, Burst Suppression
In brief
The goal of this clinical trial is to determine whether remifentanil has a facilitating effect on the generation of burst suppression by propofol in adult patients (18-60 years) candidates for elective surgery who require remifentanil and American Society of Anesthesiology (ASA) classification I or II. The main question it aims to answer are: • To determine whether remifentanil has a facilitating effect on the generation of burst suppression by propofol. Participants will undergo general anesthesia with remifentanil and propofol sequentially. After loss of consciousness, remifentanil will be adjusted to a medium or high concentration randomly and it will be determined at what concentration of propofol the burst suppressions are generated. Then, the concentrations of propofol that generate burst suppression associated with either a medium or high concentration of remifentanil will be compared.
Key facts
- Study ID
- NCT06237101
- Run by
- University of Chile
- People needed
- 20
- Starts
- 2024-03-01
- Expected to finish
- 2026-09-30
- Last updated by the study team
- 2025-11-20
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- American Society of Anesthesiology I or II
- Elective surgery of low or intermediate risk
You may not qualify if…
- Neurological disease
- Psychiatric disease
- Use of psychoactive drugs or opioids
- Altered basal state of consciousness
- Allergy to propofol
- Body mass index > 35 kg/m2
- Pre-existing renal, cardiac and/or hepatic dysfunction
- Patient's refusal to participate
Where it is running
- Centro de Investigación Cínica Avanzada (CICA), Hospital Clinico de la Universidad de Chile — Santiago, RM, Chile (enrolling)
- Hospital Clinico de la Universidad de Chile — Santiago, RM, Chile (enrolling)
Full record on ClinicalTrials.gov
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