A Study of LY3841136 Compared With Placebo in Adult Participants With Obesity or Overweight

Completed · Phase 2 · Has a placebo group

Conditions studied: Obesity, Overweight

In brief

The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to investigate weight management efficacy and safety with LY3841136 compared with placebo in adult participants with obesity or overweight. The study will last about 64 weeks and may include up to 17 visits.

Key facts

Study ID

NCT06230523

Run by

Eli Lilly and Company

People needed

263

Starts

2024-02-05

Expected to finish

2025-08-14

Last updated by the study team

2026-06-24

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• W8M-MC-LAA1
• Are males and females who agree to abide by the reproductive and contraceptive requirements
• W8M-MC-CWMM:
• Have a body mass index (BMI)
• ≥30 kilogram/square meter (kg/m²), or
• ≥27 kg/m² and <30 kg/m², or with at least 1 weight-related comorbidity
• Have had a stable body weight for the 3 months prior to randomization (<5%) body weight gain and/or loss.

You may not qualify if…

• W8M-MC-LAA1
• Have any prior diagnosis of diabetes mellitus except gestational diabetes.
• Have any of the following cardiovascular conditions within 6 months prior to screening:
• acute myocardial infarction
• cerebrovascular accident (stroke)
• unstable angina, or
• hospitalization due to congestive heart failure (CHF).
• Have a history of acute or chronic pancreatitis.
• Have an on-going or history of bradyarrhythmia and/or sinus bradycardia at screening and baseline.
• W8M-MC-CWMM
• Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed >1 year prior to screening.
• Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history of ketoacidosis or hyperosmolar coma.
• Have poorly controlled hypertension.
• Have a history of symptomatic gallbladder disease within the past 2 years
• Have signs and symptoms of any liver disease other than nonalcoholic fatty liver disease.
• Have a lifetime history of suicide attempts.

Where it is running

• The Institute for Liver Health II dba Arizona Clinical Trials - Mesa — Chandler, Arizona, United States
• Headlands Research - Scottsdale — Scottsdale, Arizona, United States
• The Institute for Liver Health II dba Arizona Liver Health-Tucson — Tucson, Arizona, United States
• NorCal Medical Research, Inc — Greenbrae, California, United States
• Velocity Clinical Research, Huntington Park — Huntington Park, California, United States
• Peninsula Research Associates — Rolling Hills Estates, California, United States
• Diablo Clinical Research, Inc. — Walnut Creek, California, United States
• Northeast Research Institute (NERI) — Fleming Island, Florida, United States
• Suncoast Clinical Research, Inc. — New Port Richey, Florida, United States
• Charter Research - Winter Park — Orlando, Florida, United States
• Charter Research - Lady Lake — The Villages, Florida, United States
• Pacific Diabetes & Endocrine Center — Honolulu, Hawaii, United States
• Medical Research Partners — Ammon, Idaho, United States
• Great Lakes Clinical Trials - Andersonville — Chicago, Illinois, United States
• Great Lakes Clinical Trials - Ravenswood — Chicago, Illinois, United States
• NorthShore University Health System — Skokie, Illinois, United States
• Iowa Diabetes and Endocrinology Research Center — West Des Moines, Iowa, United States
• Cotton O'Neil Diabetes & Endocrinology — Topeka, Kansas, United States
• L-MARC Research Center — Louisville, Kentucky, United States
• Knownwell — Needham, Massachusetts, United States
• Lucida Clinical Trials — New Bedford, Massachusetts, United States
• Headlands Research - Detroit — Southfield, Michigan, United States
• Arcturus Healthcare , PLC, Troy Internal Medicine Research Division — Troy, Michigan, United States
• StudyMetrix Research — City of Saint Peters, Missouri, United States
• Las Vegas Medical Research — Las Vegas, Nevada, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.