T-Mem GEne in Atherosclerosis
Recruiting now
Conditions studied: Atherosclerosis
In brief
Atherosclerosis is the main cause of cardiovascular diseases and is characterized by the progressive accumulation of lipids and inflammatory cells such as macrophages and lymphocytes within the vessel wall of large and medium-sized arteries, forming the so-called "atherosclerotic plaques". The formation process of these lesions is different depending on the age, genetics and physiological state of the individual affected. Furthermore, behavioral factors and the lifestyle of each individual play a key role, which can lead to the presence of a series of pro-atherosclerotic pathologies and risk factors, such as in particular systemic arterial hypertension, dyslipidemia, hyperglycemia and cigarette smoking. However, the precise molecular mechanisms underlying this pathogenetic process are still under investigation. The results of a study conducted in the past in collaboration between the U.O. have recently been published. of Vascular Surgery and the laboratory of Dr. I. Zucchi of the Institute of Biomedical Technologies of the CNR of Milan Segrate (Protocol GEMMA NUOVA, 16/int/2016), which describes that the overexpression of a newly identified gene (TMEM230) it may have a role in the formation of atherosclerotic vascular disorders, but it is still unclear how the expression of this gene is modulated in vivo. Knowledge of these factors would increase the knowledge of the molecular mechanisms underlying atherosclerosis and could represent a possible target for prevention and targeted pharmacological treatment, with consequent potential reduction in disability or mortality from cardiovascular diseases.
Key facts
- Study ID
- NCT06230406
- Run by
- IRCCS Policlinico S. Donato
- People needed
- 12
- Starts
- 2023-09-28
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2026-04-07
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- adult patients (age > 18 years)
- consent to participate in the study,
- patients coming to the Vascular Surgery Unit I of the IRCCS Policlinico San Donato for a vascular pathology of the arterial or venous district worthy of surgical treatment.
You may not qualify if…
- minor patients,
- patients who have not given their consent to participate in the study,
- patients who have vascular pathologies of the arterial or venous district not susceptible to surgical intervention.
Where it is running
- I.R.C.C.S. Policlinico San Donato — San Donato Milanese, Milan, Italy (enrolling)
Full record on ClinicalTrials.gov
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