Effect of PEEP on TRJV in Mechanically Intubated Pediatric Patients

Completed · Not applicable

Conditions studied: Tricuspid Regurgitation, Mechanical Ventilation Pressure High, Pediatric Respiratory Diseases

In brief

Prospective observational cohort study within the Pediatric Intensive Care Unit (PICU). We will perform point-of-care-ultrasound (POCUS) to quantify tricuspid regurgitant jet velocity (TRJV) on mechanically ventilated (MV) children. Mechanically ventilated (MV) children approaching extubation as per the discretion of the PICU clinical team will undergo a positive end expiratory pressure (PEEP) titration protocol in a safe and timely manner in the PICU. During this PEEP titration, POCUS will be performed by a pediatric intensivist and interpreted by a pediatric cardiologist. Medical demographics will be collected from the electronic medical record and recorded.

Key facts

Study ID

NCT06229886

Run by

Northwell Health

People needed

20

Starts

2023-12-06

Expected to finish

2024-09-21

Last updated by the study team

2024-09-26

Who can join

Age: 0 and older, up to 18. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients admitted to Cohen Children's Medical Center (CCMC) PICU who are age 3 months - 18 years old who are invasively mechanically ventilated (oral or nasotracheally).
• Patients on or approaching extubation readiness trial.
• Patients with structurally normal heart.
• Patients with normally functioning heart.
• Consent by a legal guardian.

You may not qualify if…

• Patients with known air-leak syndrome.
• Patients with history of congenital heart disease (CHD) (pre/post repair).
• Patients with significant cardiac dysfunction and/or on vasoactive medications.
• Patients with history of cardiomyopathy.
• Patients with history of pulmonary hypertension.
• Patients with history of chronic respiratory failure.
• Patients with known mediastinal mass.
• Patients with tracheostomy.

Where it is running

• Cohen Children's Medical Center — New Hyde Park, New York, United States

Full record on ClinicalTrials.gov

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