Effect of Transcranial Alternative Current Stimulation at Alpha Frequency (α-tACS) on Stressed Healthy Subjects
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Healthy
In brief
stress. Notably, several studies reported that stress could alter impulsivity, source monitoring, and time perception. Several mechanisms are involved in the response to a stress factor, among them the hypothalamic-pituitary-adrenal (HPA) axis. The cortisol reactivity (it means the cortisol secretion after the exposure to a standardized stress factor) is a reliable tool to assess the function of HPA. Cortisol secretion is bidirectionally influenced by the prefrontal cortex (PFC), which is involved in the expression and regulation of stress as well. The asymmetry of the alpha band (AFα) is a well known electrophysiological parameter to assess the function of PFC. More precisely, AFα is arising a growing interest, as it is believed to be correlated with the cortisol reactivity. Modifying this asymmetry could influence the stress response. Transcranial Alternating Current Stimulation (tACS) consists in delivering a sinusoidal alternating current between two electrodes placed on the scalp at a predefined frequency. Previous studious reported that tACS, if delivered at the alpha frequency, increased the alpha band in the stimulated areas
Key facts
- Study ID
- NCT06229002
- Run by
- Hôpital le Vinatier
- People needed
- 40
- Starts
- 2024-01-24
- Expected to finish
- 2028-02-01
- Last updated by the study team
- 2024-03-07
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Right-handed Men and Women aged between 18 and 45
- If woman, hormonal contraception required
- Having given their written informed consent
- Affiliated with a social security scheme
- French speakers and readers
You may not qualify if…
- Contraindication to the exposure to exposure to tACS
- Current psychiatric disorder as classified in the DSM-5
- Regular intake of any psychotropic drug or Beta Blocker
- Recent exposure to a traumatic event
- Any debilitating condition making the experimental procedure not feasible
- Pregnancy
Where it is running
- Centre Hospitalier Le Vinatier — Bron, AURA, France (enrolling)
Full record on ClinicalTrials.gov
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